The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.

2.50
Hdl Handle:
http://hdl.handle.net/11287/592576
Title:
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
Authors:
Pranjol, Md Zahidul Islam; Gutowski, Nicholas J.; Hannemann, Michael; Whatmore, J
Abstract:
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies and has a poor prognosis due to relatively unspecific early symptoms, and thus often advanced stage, metastasized cancer at presentation. Metastasis of EOC occurs primarily through the transcoelomic route whereby exfoliated tumor cells disseminate within the abdominal cavity, particularly to the omentum. Primary and metastatic tumor growth requires a pool of proangiogenic factors in the microenvironment which propagate new vasculature in the growing cancer. Recent evidence suggests that proangiogenic factors other than the widely known, potent angiogenic factor vascular endothelial growth factor may mediate growth and metastasis of ovarian cancer. In this review we examine the role of some of these alternative factors, specifically cathepsin D and cathepsin L.
Citation:
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer. 2015, 5 (4):3260-79 Biomolecules
Publisher:
MDPI
Journal:
Biomolecules
Issue Date:
20-Nov-2015
URI:
http://hdl.handle.net/11287/592576
DOI:
10.3390/biom5043260
PubMed ID:
26610586
Additional Links:
http://www.mdpi.com/2218-273X/5/4/3260
Type:
Journal Article
Language:
en
Description:
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN:
2218-273X
Appears in Collections:
2015 RD&E publications; Neurology; Obstetrics, Gynaecology & Maternity Services

Full metadata record

DC FieldValue Language
dc.contributor.authorPranjol, Md Zahidul Islamen
dc.contributor.authorGutowski, Nicholas J.en
dc.contributor.authorHannemann, Michaelen
dc.contributor.authorWhatmore, Jen
dc.date.accessioned2015-12-23T13:59:25Zen
dc.date.available2015-12-23T13:59:25Zen
dc.date.issued2015-11-20en
dc.identifier.citationThe Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer. 2015, 5 (4):3260-79 Biomoleculesen
dc.identifier.issn2218-273Xen
dc.identifier.pmid26610586en
dc.identifier.doi10.3390/biom5043260en
dc.identifier.urihttp://hdl.handle.net/11287/592576en
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.description.abstractEpithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies and has a poor prognosis due to relatively unspecific early symptoms, and thus often advanced stage, metastasized cancer at presentation. Metastasis of EOC occurs primarily through the transcoelomic route whereby exfoliated tumor cells disseminate within the abdominal cavity, particularly to the omentum. Primary and metastatic tumor growth requires a pool of proangiogenic factors in the microenvironment which propagate new vasculature in the growing cancer. Recent evidence suggests that proangiogenic factors other than the widely known, potent angiogenic factor vascular endothelial growth factor may mediate growth and metastasis of ovarian cancer. In this review we examine the role of some of these alternative factors, specifically cathepsin D and cathepsin L.en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urlhttp://www.mdpi.com/2218-273X/5/4/3260en
dc.rightsArchived with thanks to Biomoleculesen
dc.titleThe Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.en
dc.typeJournal Articleen
dc.identifier.journalBiomoleculesen
dc.type.versionPublisheden

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