A prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: incidence and risk factors

2.50
Hdl Handle:
http://hdl.handle.net/11287/593888
Title:
A prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: incidence and risk factors
Authors:
Park, Jonathan C.; Ramasamy, B.; Shaw, S.; Prasad, S.; Ling, Roland H.
Abstract:
BACKGROUND/AIMS: This is the first nationwide prospective study to investigate the incidence and risk factors of endophthalmitis following pars plana vitrectomy (PPV). METHODS: This was a prospective, nationwide case-control study. Cases of presumed infectious endophthalmitis within 6 weeks of PPV were reported via the established British Ophthalmological Surveillance Unit. The surveillance period was 2 years. Controls (patients who had PPV but no endophthalmitis) were recruited from nine randomly selected UK centres. RESULTS: 37 reports were received and 28 cases met the diagnostic criteria for presumed infectious endophthalmitis following PPV. The incidence of endophthalmitis following PPV was 28 cases per 48 433 PPVs (1 in 1730 with a 95% CI of 1 in 1263 to 1 in 2747). 272 controls were randomly recruited from nine UK centres. Smaller gauge port sizes were not found to be a risk. Immunosuppression (OR 19.0, p=0.001) and preoperative topical steroids (OR 131.4, p<0.001) increased the endophthalmitis risk. Operating for retinal detachment was associated with a reduced risk of endophthalmitis (OR 0.10, p=0.005). CONCLUSIONS: Endophthalmitis following PPV is rare. Operating with smaller gauge port sizes does not increase the risk of endophthalmitis.
Citation:
Br J Ophthalmol. 2014 Apr;98(4):529-33.
Publisher:
BMJ
Journal:
The British journal of ophthalmology
Issue Date:
1-Apr-2014
URI:
http://hdl.handle.net/11287/593888
DOI:
10.1136/bjophthalmol-2013-304485
PubMed ID:
24420916
Additional Links:
http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=24420916
Note:
RD&E staff can access the full-text of this article by clicking on the 'Additional Link' above and logging in with NHS OpenAthens if prompted.
Type:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Language:
eng
ISSN:
1468-2079
Appears in Collections:
Ophthalmology (West of England Eye Unit); 2014 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPark, Jonathan C.en
dc.contributor.authorRamasamy, B.en
dc.contributor.authorShaw, S.en
dc.contributor.authorPrasad, S.en
dc.contributor.authorLing, Roland H.en
dc.date.accessioned2016-01-19T12:36:22Zen
dc.date.available2016-01-19T12:36:22Zen
dc.date.issued2014-04-01en
dc.identifier.citationBr J Ophthalmol. 2014 Apr;98(4):529-33.en
dc.identifier.issn1468-2079en
dc.identifier.pmid24420916en
dc.identifier.doi10.1136/bjophthalmol-2013-304485en
dc.identifier.urihttp://hdl.handle.net/11287/593888en
dc.description.abstractBACKGROUND/AIMS: This is the first nationwide prospective study to investigate the incidence and risk factors of endophthalmitis following pars plana vitrectomy (PPV). METHODS: This was a prospective, nationwide case-control study. Cases of presumed infectious endophthalmitis within 6 weeks of PPV were reported via the established British Ophthalmological Surveillance Unit. The surveillance period was 2 years. Controls (patients who had PPV but no endophthalmitis) were recruited from nine randomly selected UK centres. RESULTS: 37 reports were received and 28 cases met the diagnostic criteria for presumed infectious endophthalmitis following PPV. The incidence of endophthalmitis following PPV was 28 cases per 48 433 PPVs (1 in 1730 with a 95% CI of 1 in 1263 to 1 in 2747). 272 controls were randomly recruited from nine UK centres. Smaller gauge port sizes were not found to be a risk. Immunosuppression (OR 19.0, p=0.001) and preoperative topical steroids (OR 131.4, p<0.001) increased the endophthalmitis risk. Operating for retinal detachment was associated with a reduced risk of endophthalmitis (OR 0.10, p=0.005). CONCLUSIONS: Endophthalmitis following PPV is rare. Operating with smaller gauge port sizes does not increase the risk of endophthalmitis.en
dc.language.isoengen
dc.publisherBMJen
dc.relation.urlhttp://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=24420916en
dc.titleA prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: incidence and risk factorsen
dc.typeJournal Articleen
dc.typeMulticenter Studyen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalThe British journal of ophthalmologyen
dc.description.noteRD&E staff can access the full-text of this article by clicking on the 'Additional Link' above and logging in with NHS OpenAthens if prompted.en

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