The effect of dietary nitrate supplementation on the oxygen cost of cycling, walking performance and resting blood pressure in individuals with chronic obstructive pulmonary disease: A double blind placebo controlled, randomised control trial

2.50
Hdl Handle:
http://hdl.handle.net/11287/593925
Title:
The effect of dietary nitrate supplementation on the oxygen cost of cycling, walking performance and resting blood pressure in individuals with chronic obstructive pulmonary disease: A double blind placebo controlled, randomised control trial
Authors:
Shepherd, Anthony I.; Wilkerson, D. P.; Dobson, L.; Kelly, J.; Winyard, Paul G.; Jones, Angus M.; Benjamin, N.; Shore, Angela ( 0000-0003-3039-308x ) ; Gilchrist, Mark
Abstract:
BACKGROUND: Chronic obstructive pulmonary disease (COPD) results in exercise intolerance. Dietary nitrate supplementation has been shown to lower blood pressure (BP), reduce the oxygen cost of exercise, and enhance exercise tolerance in healthy volunteers. This study assessed the effects of dietary nitrate on the oxygen cost of cycling, walking performance and BP in individuals with mild-moderate COPD. METHODS: Thirteen patients with mild-moderate COPD were recruited. Participants consumed 70 ml of either nitrate-rich (6.77 mmol nitrate; beetroot juice) or nitrate-depleted beetroot juice (0.002 mmol nitrate; placebo) twice a day for 2.5 days, with the final supplement ~3 hours before testing. BP was measured before completing two bouts of moderate-intensity cycling, where pulmonary gas exchange was measured throughout. The six-minute walk test (6 MWT) was completed 30 minutes subsequent to the second cycling bout. RESULTS: Plasma nitrate concentration was significantly elevated following beetroot juice vs. placebo (placebo; 48 +/- 86 vs. beetroot juice; 215 +/- 84 microM, P = 0.002). No significant differences were observed between placebo vs. beetroot juice for oxygen cost of exercise (933 +/- 323 vs. 939 +/- 302 ml: min(-1); P = 0.88), distance covered in the 6 MWT (456 +/- 86 vs. 449 +/- 79 m; P = 0.37), systolic BP (123 +/- 14 vs. 123 +/- 14 mmHg; P = 0.91), or diastolic BP (77 +/- 9 vs. 79 +/- 9 mmHg; P = 0.27). CONCLUSION: Despite a large rise in plasma nitrate concentration, two days of nitrate supplementation did not reduce the oxygen cost of moderate intensity cycling, increase distance covered in the 6 MWT, or lower BP.
Citation:
Nitric Oxide. 2015 Aug 1;48:31-7.
Publisher:
Elsevier
Journal:
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society
Issue Date:
1-Aug-2015
URI:
http://hdl.handle.net/11287/593925
DOI:
10.1016/j.niox.2015.01.002
PubMed ID:
25596150
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S1089-8603(15)00003-8
Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
eng
ISSN:
1089-8611
Appears in Collections:
2015 RD&E publications; Cardiology; Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShepherd, Anthony I.en
dc.contributor.authorWilkerson, D. P.en
dc.contributor.authorDobson, L.en
dc.contributor.authorKelly, J.en
dc.contributor.authorWinyard, Paul G.en
dc.contributor.authorJones, Angus M.en
dc.contributor.authorBenjamin, N.en
dc.contributor.authorShore, Angelaen
dc.contributor.authorGilchrist, Marken
dc.date.accessioned2016-01-19T12:37:25Zen
dc.date.available2016-01-19T12:37:25Zen
dc.date.issued2015-08-01en
dc.identifier.citationNitric Oxide. 2015 Aug 1;48:31-7.en
dc.identifier.issn1089-8611en
dc.identifier.pmid25596150en
dc.identifier.doi10.1016/j.niox.2015.01.002en
dc.identifier.urihttp://hdl.handle.net/11287/593925en
dc.description.abstractBACKGROUND: Chronic obstructive pulmonary disease (COPD) results in exercise intolerance. Dietary nitrate supplementation has been shown to lower blood pressure (BP), reduce the oxygen cost of exercise, and enhance exercise tolerance in healthy volunteers. This study assessed the effects of dietary nitrate on the oxygen cost of cycling, walking performance and BP in individuals with mild-moderate COPD. METHODS: Thirteen patients with mild-moderate COPD were recruited. Participants consumed 70 ml of either nitrate-rich (6.77 mmol nitrate; beetroot juice) or nitrate-depleted beetroot juice (0.002 mmol nitrate; placebo) twice a day for 2.5 days, with the final supplement ~3 hours before testing. BP was measured before completing two bouts of moderate-intensity cycling, where pulmonary gas exchange was measured throughout. The six-minute walk test (6 MWT) was completed 30 minutes subsequent to the second cycling bout. RESULTS: Plasma nitrate concentration was significantly elevated following beetroot juice vs. placebo (placebo; 48 +/- 86 vs. beetroot juice; 215 +/- 84 microM, P = 0.002). No significant differences were observed between placebo vs. beetroot juice for oxygen cost of exercise (933 +/- 323 vs. 939 +/- 302 ml: min(-1); P = 0.88), distance covered in the 6 MWT (456 +/- 86 vs. 449 +/- 79 m; P = 0.37), systolic BP (123 +/- 14 vs. 123 +/- 14 mmHg; P = 0.91), or diastolic BP (77 +/- 9 vs. 79 +/- 9 mmHg; P = 0.27). CONCLUSION: Despite a large rise in plasma nitrate concentration, two days of nitrate supplementation did not reduce the oxygen cost of moderate intensity cycling, increase distance covered in the 6 MWT, or lower BP.en
dc.language.isoengen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S1089-8603(15)00003-8en
dc.titleThe effect of dietary nitrate supplementation on the oxygen cost of cycling, walking performance and resting blood pressure in individuals with chronic obstructive pulmonary disease: A double blind placebo controlled, randomised control trialen
dc.typeJournal Articleen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalNitric oxide : biology and chemistry / official journal of the Nitric Oxide Societyen

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