Trends in operative caseload and mortality rates after radical cystectomy for bladder cancer in England for 1998-2010

2.50
Hdl Handle:
http://hdl.handle.net/11287/593929
Title:
Trends in operative caseload and mortality rates after radical cystectomy for bladder cancer in England for 1998-2010
Authors:
Hounsome, L. S.; Verne, J.; McGrath, John S; Gillatt, D. A.
Abstract:
BACKGROUND: The Improving Outcomes in Urological Cancers guidelines recommended centralisation of cystectomy services to improve outcomes for bladder cancer (BCa) patients. OBJECTIVE: To investigate trends in all-cause and cause-specific survival to see if there was an improvement in survival after centralisation was implemented. To analyse trends in the number of acute hospital trusts undertaking cystectomy. DESIGN, SETTING, AND PARTICIPANTS: We used routine data to capture information on radical cystectomy (RC) in BCa patients aged 20 yr and older between 1998 and 2010 (n=16,033). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We calculated 30-d and 90-d mortality, and 30-d, 90-d, 1-yr, and 5-yr survival. The average number of RCs per trust was derived. Trends were identified using regression analysis. RESULTS AND LIMITATIONS: The 30-d crude mortality decreased from 5.2% to 2.1% (p<0.001) and 90-d crude mortality decreased from 10.3% to 5.1% (p<0.001). There was an increase in 30-d relative survival from 96% to 98% (p<0.001), in 90-d relative survival from 91% to 96% (p<0.001), in 1-yr relative survival from 71% to 80% (p<0.001), and in 5-yr relative survival from 49% to 56% (2004-2006 data; p<0.001). The mean number of RCs performed by trusts in England increased from six to 24 (p<0.001). Smoking status and stage at diagnosis were not available. CONCLUSIONS: Survival after RC has increased alongside decreases in short-term mortality. There is little evidence of a cohort effect. The trends in survival are linear and we conclude that the continued survival improvements are a result of a combination of service improvements that include service reconfiguration, improved surgical training, neoadjuvant chemotherapy, enhanced recovery principles, and continued improvements in perioperative care. PATIENT SUMMARY: We analysed routinely collected hospital data. Outcomes for patients who undergo cystectomy have improved for all age groups. This is likely to be due to a combination of changes in practice.
Citation:
Eur Urol. 2015 Jun;67(6):1056-62.
Publisher:
Elsevier
Journal:
European urology
Issue Date:
1-Jun-2015
URI:
http://hdl.handle.net/11287/593929
DOI:
10.1016/j.eururo.2014.12.002
PubMed ID:
25530608
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0302-2838(14)01251-2
Type:
Journal Article
Language:
eng
ISSN:
1873-7560
Appears in Collections:
2015 RD&E publications; Urology; Urology; HeSRU publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHounsome, L. S.en
dc.contributor.authorVerne, J.en
dc.contributor.authorMcGrath, John Sen
dc.contributor.authorGillatt, D. A.en
dc.date.accessioned2016-01-19T12:37:28Zen
dc.date.available2016-01-19T12:37:28Zen
dc.date.issued2015-06-01en
dc.identifier.citationEur Urol. 2015 Jun;67(6):1056-62.en
dc.identifier.issn1873-7560en
dc.identifier.pmid25530608en
dc.identifier.doi10.1016/j.eururo.2014.12.002en
dc.identifier.urihttp://hdl.handle.net/11287/593929en
dc.description.abstractBACKGROUND: The Improving Outcomes in Urological Cancers guidelines recommended centralisation of cystectomy services to improve outcomes for bladder cancer (BCa) patients. OBJECTIVE: To investigate trends in all-cause and cause-specific survival to see if there was an improvement in survival after centralisation was implemented. To analyse trends in the number of acute hospital trusts undertaking cystectomy. DESIGN, SETTING, AND PARTICIPANTS: We used routine data to capture information on radical cystectomy (RC) in BCa patients aged 20 yr and older between 1998 and 2010 (n=16,033). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We calculated 30-d and 90-d mortality, and 30-d, 90-d, 1-yr, and 5-yr survival. The average number of RCs per trust was derived. Trends were identified using regression analysis. RESULTS AND LIMITATIONS: The 30-d crude mortality decreased from 5.2% to 2.1% (p<0.001) and 90-d crude mortality decreased from 10.3% to 5.1% (p<0.001). There was an increase in 30-d relative survival from 96% to 98% (p<0.001), in 90-d relative survival from 91% to 96% (p<0.001), in 1-yr relative survival from 71% to 80% (p<0.001), and in 5-yr relative survival from 49% to 56% (2004-2006 data; p<0.001). The mean number of RCs performed by trusts in England increased from six to 24 (p<0.001). Smoking status and stage at diagnosis were not available. CONCLUSIONS: Survival after RC has increased alongside decreases in short-term mortality. There is little evidence of a cohort effect. The trends in survival are linear and we conclude that the continued survival improvements are a result of a combination of service improvements that include service reconfiguration, improved surgical training, neoadjuvant chemotherapy, enhanced recovery principles, and continued improvements in perioperative care. PATIENT SUMMARY: We analysed routinely collected hospital data. Outcomes for patients who undergo cystectomy have improved for all age groups. This is likely to be due to a combination of changes in practice.en
dc.language.isoengen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0302-2838(14)01251-2en
dc.titleTrends in operative caseload and mortality rates after radical cystectomy for bladder cancer in England for 1998-2010en
dc.typeJournal Articleen
dc.identifier.journalEuropean urologyen

Related articles on PubMed

All Items in RD&E Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.