Molecular insights into the aetiology of female reproductive ageing

2.50
Hdl Handle:
http://hdl.handle.net/11287/593966
Title:
Molecular insights into the aetiology of female reproductive ageing
Authors:
Perry, J. R.; Murray, Anna; Day, F. R.; Ong, K. K.
Abstract:
As age at pubertal onset declines and age at first pregnancy increases, the mechanisms that regulate female reproductive lifespan become increasingly relevant to population health. The timing of menarche and menopause can have profound effects not only on fertility but also on the risk of diseases such as type 2 diabetes mellitus, cardiovascular disease and breast cancer. Genetic studies have identified dozens of highly penetrant rare mutations associated with reproductive disorders, and also approximately 175 common genetic variants associated with the timing of puberty or menopause. These findings, alongside other functional studies, have highlighted a diverse range of mechanisms involved in reproductive ageing, implicating core biological processes such as cell cycle regulation and energy homeostasis. The aim of this article is to review the contribution of such genetic findings to our understanding of the molecular regulation of reproductive timing, as well as the biological basis of the epidemiological links between reproductive ageing and disease risk.
Citation:
Nat Rev Endocrinol. 2015 Dec;11(12):725-34.
Publisher:
Nature
Journal:
Nature reviews. Endocrinology
Issue Date:
13-Oct-2015
URI:
http://hdl.handle.net/11287/593966
DOI:
10.1038/nrendo.2015.167
PubMed ID:
26460341
Additional Links:
http://dx.doi.org/10.1038/nrendo.2015.167
Type:
Journal Article; Review
Language:
eng
ISSN:
1759-5037
Appears in Collections:
2015 RD&E publications; Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPerry, J. R.en
dc.contributor.authorMurray, Annaen
dc.contributor.authorDay, F. R.en
dc.contributor.authorOng, K. K.en
dc.date.accessioned2016-01-19T12:38:03Zen
dc.date.available2016-01-19T12:38:03Zen
dc.date.issued2015-10-13en
dc.identifier.citationNat Rev Endocrinol. 2015 Dec;11(12):725-34.en
dc.identifier.issn1759-5037en
dc.identifier.pmid26460341en
dc.identifier.doi10.1038/nrendo.2015.167en
dc.identifier.urihttp://hdl.handle.net/11287/593966en
dc.description.abstractAs age at pubertal onset declines and age at first pregnancy increases, the mechanisms that regulate female reproductive lifespan become increasingly relevant to population health. The timing of menarche and menopause can have profound effects not only on fertility but also on the risk of diseases such as type 2 diabetes mellitus, cardiovascular disease and breast cancer. Genetic studies have identified dozens of highly penetrant rare mutations associated with reproductive disorders, and also approximately 175 common genetic variants associated with the timing of puberty or menopause. These findings, alongside other functional studies, have highlighted a diverse range of mechanisms involved in reproductive ageing, implicating core biological processes such as cell cycle regulation and energy homeostasis. The aim of this article is to review the contribution of such genetic findings to our understanding of the molecular regulation of reproductive timing, as well as the biological basis of the epidemiological links between reproductive ageing and disease risk.en
dc.language.isoengen
dc.publisherNatureen
dc.relation.urlhttp://dx.doi.org/10.1038/nrendo.2015.167en
dc.titleMolecular insights into the aetiology of female reproductive ageingen
dc.typeJournal Articleen
dc.typeReviewen
dc.identifier.journalNature reviews. Endocrinologyen

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