Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts

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Authors
Huang, W-C
Lin, J-Y
Wallace, Christopher G
Wei, F-C
Liao, S-K
Journal
Clinical and Developmental Immunology
Type
Journal Article
Research Support, Non-U.S. Gov't
Publisher
Hindawi
Rights
Archived with thanks to Clinical and Developmental Immunology
Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions.
Citation
Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts 2012, 2012:1 Clinical and Developmental Immunology
Note
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