5-hydroxymethylcytosine is highly dynamic across human fetal brain development.

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Authors
Spiers, H.
Hannon, Eilis
Schalkwyk, L. C.
Bray, N. J.
Mill, Jonathan
Journal
BMC genomics
Type
Journal Article
Publisher
BioMed Central
Rights
Archived with thanks to BMC genomics
Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic processes operating during this period have not been extensively explored. Of particular interest is DNA hydroxymethylation (5hmC), a modification that is enriched in the human brain and hypothesized to play an important role in neuronal function, learning and memory. In this study, we quantify 5hmC across the genome of 71 human fetal brain samples spanning 23 to 184 days post-conception.
Citation
5-hydroxymethylcytosine is highly dynamic across human fetal brain development. 2017, 18 (1):738 BMC Genomics
Note
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.