PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.

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Authors
Colli, M. L.
Hill, J. L. E.
Marroquí, L.
Chaffey, J.
Dos Santos, R. S.
Leete, P.
Coomans de Brachène, A.
Paula, F. M. M.
Op de Beeck, A.
Castela, A.
Journal
EBioMedicine
Type
Journal Article
Publisher
Elsevier
Rights
Archived with thanks to EBioMedicine
Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of people with T1D and how is it regulated.
Citation
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction. 2018 Oct;36:367-375 EBioMedicine
Note
This article is freely available via Open Access.