Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population

2.50
Hdl Handle:
http://hdl.handle.net/11287/593994
Title:
Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population
Authors:
Knight, Bridget A.; Shields, Beverley M; Brook, Adam; Hill, Anita; Bhat, D. S.; Hattersley, Andrew T.; Yajnik, C. S.
Abstract:
OBJECTIVE: Vitamin B12 and folate are critical micronutrients needed to support the increased metabolic demands of pregnancy. Recent studies from India have suggested that low vitamin B12 and folate concentrations in pregnancy are associated with increased obesity; however differences in diet, antenatal vitamin supplementation, and socioeconomic status may limit the generalisability of these findings. We aimed to explore the cross-sectional relationship of circulating serum vitamin B12 and folate at 28 weeks' gestation with maternal adiposity and related biochemical markers in a white non diabetic UK obstetric cohort. METHODS: Anthropometry and biochemistry data was available on 995 women recruited at 28 weeks gestation to the Exeter Family Study of Childhood Health. Associations between B12 and folate with maternal BMI and other obesity-related biochemical factors (HOMA-R, fasting glucose, triglycerides, HDL and AST) were explored using regression analysis, adjusting for potential confounders (socioeconomic status, vegetarian diet, vitamin supplementation, parity, haemodilution (haematocrit)). RESULTS: Higher 28 week BMI was associated with lower circulating vitamin B12 (r = -0.25; P<0.001) and folate (r = -0.15; P<0.001). In multiple regression analysis higher 28 week BMI remained an independent predictor of lower circulating B12 (beta (95% CI) = -0.59 (-0.74, -0.44) i.e. for every 1% increase in BMI there was a 0.6% decrease in circulating B12). Other markers of adiposity/body fat metabolism (HOMA-R, triglycerides and AST) were also independently associated with circulating B12. In a similar multiple regression AST was the only independent obesity-related marker associated with serum folate (beta (95% CI) = 0.16 (0.21, 0.51)). CONCLUSION: In conclusion, our study has replicated the previous Indian findings of associations between lower serum B12 and higher obesity and insulin resistance during pregnancy in a non-diabetic White British population. These findings may have important implications for fetal and maternal health in obese pregnancies.
Citation:
PLoS One. 2015;10(8):e0135268.
Publisher:
PLoS One
Journal:
PloS one
Issue Date:
19-Aug-2015
URI:
http://hdl.handle.net/11287/593994
DOI:
10.1371/journal.pone.0135268
PubMed ID:
26288227
Additional Links:
http://dx.plos.org/10.1371/journal.pone.0135268
Note:
This article is available via Open Access. Please click on the 'Additional Link' above to access the full-text.
Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
eng
ISSN:
1932-6203
Appears in Collections:
2015 RD&E publications; Diabetes/Endocrine Services; Molecular Genetics; Honorary contracts publications; Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKnight, Bridget A.en
dc.contributor.authorShields, Beverley Men
dc.contributor.authorBrook, Adamen
dc.contributor.authorHill, Anitaen
dc.contributor.authorBhat, D. S.en
dc.contributor.authorHattersley, Andrew T.en
dc.contributor.authorYajnik, C. S.en
dc.date.accessioned2016-01-19T12:38:22Zen
dc.date.available2016-01-19T12:38:22Zen
dc.date.issued2015-08-19en
dc.identifier.citationPLoS One. 2015;10(8):e0135268.en
dc.identifier.issn1932-6203en
dc.identifier.pmid26288227en
dc.identifier.doi10.1371/journal.pone.0135268en
dc.identifier.urihttp://hdl.handle.net/11287/593994en
dc.description.abstractOBJECTIVE: Vitamin B12 and folate are critical micronutrients needed to support the increased metabolic demands of pregnancy. Recent studies from India have suggested that low vitamin B12 and folate concentrations in pregnancy are associated with increased obesity; however differences in diet, antenatal vitamin supplementation, and socioeconomic status may limit the generalisability of these findings. We aimed to explore the cross-sectional relationship of circulating serum vitamin B12 and folate at 28 weeks' gestation with maternal adiposity and related biochemical markers in a white non diabetic UK obstetric cohort. METHODS: Anthropometry and biochemistry data was available on 995 women recruited at 28 weeks gestation to the Exeter Family Study of Childhood Health. Associations between B12 and folate with maternal BMI and other obesity-related biochemical factors (HOMA-R, fasting glucose, triglycerides, HDL and AST) were explored using regression analysis, adjusting for potential confounders (socioeconomic status, vegetarian diet, vitamin supplementation, parity, haemodilution (haematocrit)). RESULTS: Higher 28 week BMI was associated with lower circulating vitamin B12 (r = -0.25; P<0.001) and folate (r = -0.15; P<0.001). In multiple regression analysis higher 28 week BMI remained an independent predictor of lower circulating B12 (beta (95% CI) = -0.59 (-0.74, -0.44) i.e. for every 1% increase in BMI there was a 0.6% decrease in circulating B12). Other markers of adiposity/body fat metabolism (HOMA-R, triglycerides and AST) were also independently associated with circulating B12. In a similar multiple regression AST was the only independent obesity-related marker associated with serum folate (beta (95% CI) = 0.16 (0.21, 0.51)). CONCLUSION: In conclusion, our study has replicated the previous Indian findings of associations between lower serum B12 and higher obesity and insulin resistance during pregnancy in a non-diabetic White British population. These findings may have important implications for fetal and maternal health in obese pregnancies.en
dc.language.isoengen
dc.publisherPLoS Oneen
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0135268en
dc.titleLower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Populationen
dc.typeJournal Articleen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalPloS oneen
dc.description.noteThis article is available via Open Access. Please click on the 'Additional Link' above to access the full-text.en

Related articles on PubMed

All Items in RD&E Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.