Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.

2.50
Hdl Handle:
http://hdl.handle.net/11287/602214
Title:
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
Authors:
Wood, A. R.; Tyrrell, J.; Beaumont, R.; Jones, S. E.; Tuke, M. A.; Ruth, K. S.; Yaghootkar, Hanieh; Freathy, Rachel M.; Murray, Anna; Frayling, T. M.; Weedon, M. N.
Abstract:
Genome-wide association (GWA) studies have identified hundreds of common genetic variants associated with obesity and type 2 diabetes. These studies have usually focused on additive association tests. Identifying deviations from additivity may provide new biological insights and explain some of the missing heritability for these diseases.
Citation:
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 2016 Jun;59(6):1214-21: Diabetologia
Publisher:
Springer
Journal:
Diabetologia
Issue Date:
10-Mar-2016
URI:
http://hdl.handle.net/11287/602214
DOI:
10.1007/s00125-016-3908-5
PubMed ID:
26961502
Additional Links:
http://dx.doi.org/10.1007/s00125-016-3908-5
Note:
This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1432-0428
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWood, A. R.en
dc.contributor.authorTyrrell, J.en
dc.contributor.authorBeaumont, R.en
dc.contributor.authorJones, S. E.en
dc.contributor.authorTuke, M. A.en
dc.contributor.authorRuth, K. S.en
dc.contributor.authorYaghootkar, Haniehen
dc.contributor.authorFreathy, Rachel M.en
dc.contributor.authorMurray, Annaen
dc.contributor.authorFrayling, T. M.en
dc.contributor.authorWeedon, M. N.en
dc.date.accessioned2016-03-18T11:29:52Zen
dc.date.available2016-03-18T11:29:52Zen
dc.date.issued2016-03-10en
dc.identifier.citationVariants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 2016 Jun;59(6):1214-21: Diabetologiaen
dc.identifier.issn1432-0428en
dc.identifier.pmid26961502en
dc.identifier.doi10.1007/s00125-016-3908-5en
dc.identifier.urihttp://hdl.handle.net/11287/602214en
dc.description.abstractGenome-wide association (GWA) studies have identified hundreds of common genetic variants associated with obesity and type 2 diabetes. These studies have usually focused on additive association tests. Identifying deviations from additivity may provide new biological insights and explain some of the missing heritability for these diseases.en
dc.languageENGen
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://dx.doi.org/10.1007/s00125-016-3908-5en
dc.rightsArchived with thanks to Diabetologia. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleVariants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.en
dc.typeJournal Articleen
dc.identifier.journalDiabetologiaen
dc.description.noteThis article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.en
dc.type.versionIn press (epub ahead of print)en

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