Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.

2.50
Hdl Handle:
http://hdl.handle.net/11287/605106
Title:
Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.
Authors:
Babiker, Tarig; Vedovato, N.; Patel, Kashyap; Thomas, Nicholas; Finn, Roisin; Männikkö, R.; Chakera, Ali J.; Flanagan, Sarah; Shepherd, Maggie ( 0000-0003-2660-0955 ) ; Ellard, Sian ( 0000-0002-7620-5526 ) ; Ashcroft, Frances M; Hattersley, Andrew T.
Abstract:
The finding that patients with diabetes due to potassium channel mutations can transfer from insulin to sulfonylureas has revolutionised the management of patients with permanent neonatal diabetes. The extent to which the in vitro characteristics of the mutation can predict a successful transfer is not known. Our aim was to identify factors associated with successful transfer from insulin to sulfonylureas in patients with permanent neonatal diabetes due to mutations in KCNJ11 (which encodes the inwardly rectifying potassium channel Kir6.2).
Citation:
Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. 2016 Jun;59(6):1162-6
Publisher:
Springer
Journal:
Diabetologia
Issue Date:
31-Mar-2016
URI:
http://hdl.handle.net/11287/605106
DOI:
10.1007/s00125-016-3921-8
PubMed ID:
27033559
Additional Links:
http://dx.doi.org/10.1007/s00125-016-3921-8
Note:
This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1432-0428
Appears in Collections:
Diabetes/Endocrine Services; Molecular Genetics; Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBabiker, Tarigen
dc.contributor.authorVedovato, N.en
dc.contributor.authorPatel, Kashyapen
dc.contributor.authorThomas, Nicholasen
dc.contributor.authorFinn, Roisinen
dc.contributor.authorMännikkö, R.en
dc.contributor.authorChakera, Ali J.en
dc.contributor.authorFlanagan, Sarahen
dc.contributor.authorShepherd, Maggieen
dc.contributor.authorEllard, Sianen
dc.contributor.authorAshcroft, Frances Men
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2016-04-12T15:48:25Zen
dc.date.available2016-04-12T15:48:25Zen
dc.date.issued2016-03-31en
dc.identifier.citationSuccessful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. 2016 Jun;59(6):1162-6en
dc.identifier.issn1432-0428en
dc.identifier.pmid27033559en
dc.identifier.doi10.1007/s00125-016-3921-8en
dc.identifier.urihttp://hdl.handle.net/11287/605106en
dc.description.abstractThe finding that patients with diabetes due to potassium channel mutations can transfer from insulin to sulfonylureas has revolutionised the management of patients with permanent neonatal diabetes. The extent to which the in vitro characteristics of the mutation can predict a successful transfer is not known. Our aim was to identify factors associated with successful transfer from insulin to sulfonylureas in patients with permanent neonatal diabetes due to mutations in KCNJ11 (which encodes the inwardly rectifying potassium channel Kir6.2).en
dc.languageENGen
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://dx.doi.org/10.1007/s00125-016-3921-8en
dc.rightsArchived with thanks to Diabetologia. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were madeen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleSuccessful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.en
dc.typeJournal Articleen
dc.identifier.journalDiabetologiaen
dc.description.noteThis article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.en
dc.type.versionIn press (epub ahead of print)en

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