Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?

2.50
Hdl Handle:
http://hdl.handle.net/11287/605288
Title:
Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?
Authors:
Jones, Angus G.; Lonergan, M.; Henley, W. E.; Pearson, E. R.; Hattersley, Andrew T.; Shields, Beverley M
Abstract:
Baseline HbA1c is a major predictor of response to glucose lowering therapy and therefore a potential confounder in studies aiming to identify other predictors. However, baseline adjustment may introduce error if the association between baseline HbA1c and response is substantially due to measurement error and regression to the mean. We aimed to determine whether studies of predictors of response should adjust for baseline HbA1c.
Citation:
Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c? 2016, 11 (4):e0152428 PLoS ONE
Publisher:
PLoS One
Journal:
PloS one
Issue Date:
6-Apr-2016
URI:
http://hdl.handle.net/11287/605288
DOI:
10.1371/journal.pone.0152428
PubMed ID:
27050911
Additional Links:
http://dx.plos.org/10.1371/journal.pone.0152428
Note:
This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Diabetes/Endocrine Services; Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJones, Angus G.en
dc.contributor.authorLonergan, M.en
dc.contributor.authorHenley, W. E.en
dc.contributor.authorPearson, E. R.en
dc.contributor.authorHattersley, Andrew T.en
dc.contributor.authorShields, Beverley Men
dc.date.accessioned2016-04-14T14:53:04Zen
dc.date.available2016-04-14T14:53:04Zen
dc.date.issued2016-04-06en
dc.identifier.citationShould Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c? 2016, 11 (4):e0152428 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid27050911en
dc.identifier.doi10.1371/journal.pone.0152428en
dc.identifier.urihttp://hdl.handle.net/11287/605288en
dc.description.abstractBaseline HbA1c is a major predictor of response to glucose lowering therapy and therefore a potential confounder in studies aiming to identify other predictors. However, baseline adjustment may introduce error if the association between baseline HbA1c and response is substantially due to measurement error and regression to the mean. We aimed to determine whether studies of predictors of response should adjust for baseline HbA1c.en
dc.language.isoenen
dc.publisherPLoS Oneen
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0152428en
dc.rightsArchived with thanks to PloS one. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleShould Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?en
dc.typeJournal Articleen
dc.identifier.journalPloS oneen
dc.description.noteThis article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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