Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study.

2.50
Hdl Handle:
http://hdl.handle.net/11287/606576
Title:
Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study.
Authors:
Ruth, K. S.; Perry, J. R. B.; Henley, W. E.; Melzer, David ( 0000-0002-0170-3838 ) ; Weedon, M. N.; Murray, Anna
Abstract:
The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence ('early-life risk factors') could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood in 11,781 cases (menopause aged under 45) and 173,641 controls (menopause/pre-menopausal at ≥45 years), in models controlling for potential confounding variables. Being part of a multiple birth was strongly associated with early menopause (odds ratio = 1.42, confidence interval: 1.11, 1.82, P = 8.0 × 10(-9), fully-adjusted model). Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)). We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births. We identified an association between multiple births and early menopause, which connects events pre-birth, when the oocyte pool is formed, with reproductive ageing in later life.
Citation:
Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study. 2016, 6:24710 Sci Rep
Publisher:
Nature
Journal:
Scientific reports
Issue Date:
20-Apr-2016
URI:
http://hdl.handle.net/11287/606576
DOI:
10.1038/srep24710
PubMed ID:
27094806
Additional Links:
http://dx.doi.org/10.1038/srep24710
Note:
This article is freely available via Open Access. Click on 'Additional Link' above to access the full-text from the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRuth, K. S.en
dc.contributor.authorPerry, J. R. B.en
dc.contributor.authorHenley, W. E.en
dc.contributor.authorMelzer, Daviden
dc.contributor.authorWeedon, M. N.en
dc.contributor.authorMurray, Annaen
dc.date.accessioned2016-04-22T10:44:06Zen
dc.date.available2016-04-22T10:44:06Zen
dc.date.issued2016-04-20en
dc.identifier.citationEvents in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study. 2016, 6:24710 Sci Repen
dc.identifier.issn2045-2322en
dc.identifier.pmid27094806en
dc.identifier.doi10.1038/srep24710en
dc.identifier.urihttp://hdl.handle.net/11287/606576en
dc.description.abstractThe available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence ('early-life risk factors') could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood in 11,781 cases (menopause aged under 45) and 173,641 controls (menopause/pre-menopausal at ≥45 years), in models controlling for potential confounding variables. Being part of a multiple birth was strongly associated with early menopause (odds ratio = 1.42, confidence interval: 1.11, 1.82, P = 8.0 × 10(-9), fully-adjusted model). Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10(-6)) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10(-6)). We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births. We identified an association between multiple births and early menopause, which connects events pre-birth, when the oocyte pool is formed, with reproductive ageing in later life.en
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttp://dx.doi.org/10.1038/srep24710en
dc.rightsArchived with thanks to Scientific reports. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleEvents in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study.en
dc.typeJournal Articleen
dc.identifier.journalScientific reportsen
dc.description.noteThis article is freely available via Open Access. Click on 'Additional Link' above to access the full-text from the publisher's site.en
dc.type.versionPublisheden

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