Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes.

2.50
Hdl Handle:
http://hdl.handle.net/11287/612507
Title:
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes.
Authors:
Shepherd, Maggie ( 0000-0003-2660-0955 ) ; Shields, Beverley M; Hammersley, S.; Hudson, Michelle; McDonald, Timothy J. ( 0000-0003-3559-6660 ) ; Colclough, Kevin; Oram, R. A.; Knight, Bridget A.; Hyde, C.; Cox, J.; Mallam, K.; Moudiotis, Christopher; Smith, R.; Fraser, B.; Robertson, S.; Greene, S.; Ellard, Sian ( 0000-0002-7620-5526 ) ; Pearson, E. R.; Hattersley, Andrew T.
Abstract:
Monogenic diabetes is rare but is an important diagnosis in pediatric diabetes clinics. These patients are often not identified as this relies on the recognition of key clinical features by an alert clinician. Biomarkers (islet autoantibodies and C-peptide) can assist in the exclusion of patients with type 1 diabetes and allow systematic testing that does not rely on clinical recognition. Our study aimed to establish the prevalence of monogenic diabetes in U.K. pediatric clinics using a systematic approach of biomarker screening and targeted genetic testing.
Citation:
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes. 2016 Nov;39(11):1879-1888: Diabetes Care
Publisher:
American Diabetes Association
Journal:
Diabetes care
Issue Date:
6-Jun-2016
URI:
http://hdl.handle.net/11287/612507
DOI:
10.2337/dc16-0645
PubMed ID:
27271189
Additional Links:
http://care.diabetesjournals.org/content/early/2016/05/23/dc16-0645.article-info
Type:
Journal Article
Language:
en
Description:
This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association (ADA), publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals.org.
ISSN:
1935-5548
Appears in Collections:
Diabetes/Endocrine Services; Paediatrics; Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology); Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShepherd, Maggieen
dc.contributor.authorShields, Beverley Men
dc.contributor.authorHammersley, S.en
dc.contributor.authorHudson, Michelleen
dc.contributor.authorMcDonald, Timothy J.en
dc.contributor.authorColclough, Kevinen
dc.contributor.authorOram, R. A.en
dc.contributor.authorKnight, Bridget A.en
dc.contributor.authorHyde, C.en
dc.contributor.authorCox, J.en
dc.contributor.authorMallam, K.en
dc.contributor.authorMoudiotis, Christopheren
dc.contributor.authorSmith, R.en
dc.contributor.authorFraser, B.en
dc.contributor.authorRobertson, S.en
dc.contributor.authorGreene, S.en
dc.contributor.authorEllard, Sianen
dc.contributor.authorPearson, E. R.en
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2016-06-10T14:28:54Z-
dc.date.available2016-06-10T14:28:54Z-
dc.date.issued2016-06-06-
dc.identifier.citationSystematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes. 2016 Nov;39(11):1879-1888: Diabetes Careen
dc.identifier.issn1935-5548-
dc.identifier.pmid27271189-
dc.identifier.doi10.2337/dc16-0645-
dc.identifier.urihttp://hdl.handle.net/11287/612507-
dc.descriptionThis is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association (ADA), publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals.org.-
dc.description.abstractMonogenic diabetes is rare but is an important diagnosis in pediatric diabetes clinics. These patients are often not identified as this relies on the recognition of key clinical features by an alert clinician. Biomarkers (islet autoantibodies and C-peptide) can assist in the exclusion of patients with type 1 diabetes and allow systematic testing that does not rely on clinical recognition. Our study aimed to establish the prevalence of monogenic diabetes in U.K. pediatric clinics using a systematic approach of biomarker screening and targeted genetic testing.en
dc.languageENG-
dc.language.isoenen
dc.publisherAmerican Diabetes Associationen
dc.relation.urlhttp://care.diabetesjournals.org/content/early/2016/05/23/dc16-0645.article-infoen
dc.rightsArchived with thanks to Diabetes Care. This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association (ADA), publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals.org.en
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Paediatricsen
dc.titleSystematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes.en
dc.typeJournal Articleen
dc.identifier.journalDiabetes careen
dc.type.versionIn press (epub ahead of print)en

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