Early oxygen uptake recovery following exercise testing in children with chronic chest diseases.

2.50
Hdl Handle:
http://hdl.handle.net/11287/615955
Title:
Early oxygen uptake recovery following exercise testing in children with chronic chest diseases.
Authors:
Stevens, D; Oades, Patrick ( 0000-0001-5265-6923 ) ; Armstrong, N; Williams, Craig A.
Abstract:
The value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake (VO2) during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relation to functional capacity and markers of disease severity. Twenty-seven children with CCD (age 12.7 +/- 3.1 years; 17 female) [19 children with Cystic fibrosis (CF) (age 13.4 +/- 3.1 years; 10 female) and 8 with other stable non-CF chest diseases (NON-CF) (age 11.1 +/- 2.2 years; 7 female)] and 27 healthy controls (age 13.2 +/- 3.3 years; 17 female) underwent CPXT on a cycle ergometer. On-line respiratory gas analysis measured VO2 before and during CPXT to peak VO2) (VO2(peak)), and during the first 10 min of recovery. Early VO2 recovery was quantified by the time (sec) to reach 50% of the VO2 (peak) value. Early VO2 recovery was correlated against spirometry [forced expiratory volume in 1 sec (FEV(1)) and forced expiratory flow between 25% and 75% of the forced vital capacity (FEF(25-75))] and aerobic fitness (VO2)(peak)) as a measure of functional capacity. Disease severity was graded in the CF patients by the Shwachman score (SS). Compared to controls, children with CCD demonstrated a significantly reduced VO2(peak) (P = 0.011), FEV(1) (P < 0.001), FEF(25-75) (P < 0.001), and a significantly prolonged early (VO2) recovery (P = 0.024). In the CF patients the SS was significantly correlated with early VO2 recovery (r = -0.63, P = 0.004), FEV(1) (r = 0.72, P = 0.001), and FEF(25-75) (r = 0.57, P = 0.011). In the children with CCD, FEV(1), FEF(25-75), and BMI were not significantly correlated with VO2(peak) or early VO2 recovery. Lung function does not necessarily reflect aerobic fitness and the ability to recover from exercise in these patients. A significant relationship was found between VO2(peak) and early VO2 recovery (r = -0.39, P = 0.044) in the children with CCD, showing that a greater aerobic fitness corresponded with a faster recovery.
Citation:
Early oxygen uptake recovery following exercise testing in children with chronic chest diseases. 2009, 44 (5):480-8 Pediatr. Pulmonol.
Publisher:
Wiley
Journal:
Pediatric pulmonology
Issue Date:
May-2009
URI:
http://hdl.handle.net/11287/615955
DOI:
10.1002/ppul.21024
PubMed ID:
19382220
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/ppul.21024/abstract;jsessionid=588CCF056B8E7CE3254C6F525A53ADDF.f01t01
Note:
This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1099-0496
Appears in Collections:
pre-2014 RD&E publications; Paediatrics; Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorStevens, Den
dc.contributor.authorOades, Patricken
dc.contributor.authorArmstrong, Nen
dc.contributor.authorWilliams, Craig A.en
dc.date.accessioned2016-07-12T08:54:41Z-
dc.date.available2016-07-12T08:54:41Z-
dc.date.issued2009-05-
dc.identifier.citationEarly oxygen uptake recovery following exercise testing in children with chronic chest diseases. 2009, 44 (5):480-8 Pediatr. Pulmonol.en
dc.identifier.issn1099-0496-
dc.identifier.pmid19382220-
dc.identifier.doi10.1002/ppul.21024-
dc.identifier.urihttp://hdl.handle.net/11287/615955-
dc.description.abstractThe value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake (VO2) during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relation to functional capacity and markers of disease severity. Twenty-seven children with CCD (age 12.7 +/- 3.1 years; 17 female) [19 children with Cystic fibrosis (CF) (age 13.4 +/- 3.1 years; 10 female) and 8 with other stable non-CF chest diseases (NON-CF) (age 11.1 +/- 2.2 years; 7 female)] and 27 healthy controls (age 13.2 +/- 3.3 years; 17 female) underwent CPXT on a cycle ergometer. On-line respiratory gas analysis measured VO2 before and during CPXT to peak VO2) (VO2(peak)), and during the first 10 min of recovery. Early VO2 recovery was quantified by the time (sec) to reach 50% of the VO2 (peak) value. Early VO2 recovery was correlated against spirometry [forced expiratory volume in 1 sec (FEV(1)) and forced expiratory flow between 25% and 75% of the forced vital capacity (FEF(25-75))] and aerobic fitness (VO2)(peak)) as a measure of functional capacity. Disease severity was graded in the CF patients by the Shwachman score (SS). Compared to controls, children with CCD demonstrated a significantly reduced VO2(peak) (P = 0.011), FEV(1) (P < 0.001), FEF(25-75) (P < 0.001), and a significantly prolonged early (VO2) recovery (P = 0.024). In the CF patients the SS was significantly correlated with early VO2 recovery (r = -0.63, P = 0.004), FEV(1) (r = 0.72, P = 0.001), and FEF(25-75) (r = 0.57, P = 0.011). In the children with CCD, FEV(1), FEF(25-75), and BMI were not significantly correlated with VO2(peak) or early VO2 recovery. Lung function does not necessarily reflect aerobic fitness and the ability to recover from exercise in these patients. A significant relationship was found between VO2(peak) and early VO2 recovery (r = -0.39, P = 0.044) in the children with CCD, showing that a greater aerobic fitness corresponded with a faster recovery.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ppul.21024/abstract;jsessionid=588CCF056B8E7CE3254C6F525A53ADDF.f01t01en
dc.rightsArchived with thanks to Pediatric pulmonologyen
dc.subjectWessex Classification Subject Headings::Diseases & disorders of systemic, metabolic or environmental origin::Sports medicineen
dc.subjectWessex Classification Subject Headings::Paediatricsen
dc.titleEarly oxygen uptake recovery following exercise testing in children with chronic chest diseases.en
dc.typeJournal Articleen
dc.identifier.journalPediatric pulmonologyen
dc.description.noteThis article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.en
dc.type.versionPublisheden
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