Can genetic evidence help us to understand the fetal origins of type 2 diabetes?

2.50
Hdl Handle:
http://hdl.handle.net/11287/617685
Title:
Can genetic evidence help us to understand the fetal origins of type 2 diabetes?
Authors:
Freathy, Rachel M.
Abstract:
Lower birthweight is consistently associated with a higher risk of type 2 diabetes in observational studies, but the mechanisms underlying this association are not fully understood. Animal models and studies of famine-exposed populations have provided support for the developmental origins hypothesis, under which exposure to poor intrauterine nutrition results in reduced fetal growth and also contributes to the developmental programming of later type 2 diabetes risk. However, testing this hypothesis is difficult in human studies and studies aiming to do so are mostly observational and have limited scope for causal inference due to the presence of confounding factors. In this issue of Diabetologia, Wang et al (doi: 10.1007/s00125-016-4019-z ) have used genetic variation associated with birthweight in a Mendelian randomisation analysis to assess evidence of a causal link between fetal growth and type 2 diabetes. Mendelian randomisation offers the potential to examine associations between exposures and outcomes in the absence of factors that would normally confound observational studies. This commentary discusses the results of the Mendelian randomisation study carried out by Wang et al, in relation to the study design and its limitations. Challenges and opportunities for future studies are also outlined.
Citation:
Can genetic evidence help us to understand the fetal origins of type 2 diabetes? 2016 Sep;59(9):1850-4 Diabetologia
Publisher:
Springer
Journal:
Diabetologia
Issue Date:
19-Jul-2016
URI:
http://hdl.handle.net/11287/617685
DOI:
10.1007/s00125-016-4057-6
PubMed ID:
27435863
Additional Links:
http://dx.doi.org/10.1007/s00125-016-4057-6
Type:
Editorial
Language:
en
ISSN:
1432-0428
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorFreathy, Rachel M.en
dc.date.accessioned2016-07-28T11:42:39Z-
dc.date.available2016-07-28T11:42:39Z-
dc.date.issued2016-07-19-
dc.identifier.citationCan genetic evidence help us to understand the fetal origins of type 2 diabetes? 2016 Sep;59(9):1850-4 Diabetologiaen
dc.identifier.issn1432-0428-
dc.identifier.pmid27435863-
dc.identifier.doi10.1007/s00125-016-4057-6-
dc.identifier.urihttp://hdl.handle.net/11287/617685-
dc.description.abstractLower birthweight is consistently associated with a higher risk of type 2 diabetes in observational studies, but the mechanisms underlying this association are not fully understood. Animal models and studies of famine-exposed populations have provided support for the developmental origins hypothesis, under which exposure to poor intrauterine nutrition results in reduced fetal growth and also contributes to the developmental programming of later type 2 diabetes risk. However, testing this hypothesis is difficult in human studies and studies aiming to do so are mostly observational and have limited scope for causal inference due to the presence of confounding factors. In this issue of Diabetologia, Wang et al (doi: 10.1007/s00125-016-4019-z ) have used genetic variation associated with birthweight in a Mendelian randomisation analysis to assess evidence of a causal link between fetal growth and type 2 diabetes. Mendelian randomisation offers the potential to examine associations between exposures and outcomes in the absence of factors that would normally confound observational studies. This commentary discusses the results of the Mendelian randomisation study carried out by Wang et al, in relation to the study design and its limitations. Challenges and opportunities for future studies are also outlined.en
dc.languageENG-
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://dx.doi.org/10.1007/s00125-016-4057-6en
dc.rightsArchived with thanks to Diabetologiaen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleCan genetic evidence help us to understand the fetal origins of type 2 diabetes?en
dc.typeEditorialen
dc.identifier.journalDiabetologiaen
dc.type.versionIn press (epub ahead of print)en

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