Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

2.50
Hdl Handle:
http://hdl.handle.net/11287/618031
Title:
Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.
Authors:
Goncalves, I.; Bengtsson, E.; Colhoun, H. M.; Shore, Angela ( 0000-0003-3039-308x ) ; Palombo, C.; Natali, A.; Edsfeldt, A.; Dunér, P.; Fredrikson, G. N.; Björkbacka, H.; Östling, G.; Aizawa, Kunihiko; Casanova, Francesco; Persson, M.; Gooding, Kim; Strain, David; Khan, F.; Looker, H. C.; Adams, F.; Belch, J.; Pinnoli, S.; Venturi, E.; Kozakova, M.; Gan, L.-M.; Schnecke, V.; Nilsson, J.
Abstract:
Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.
Citation:
Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. 2015, 35 (7):1723-31 Arterioscler. Thromb. Vasc. Biol.
Publisher:
American Heart Association
Journal:
Arteriosclerosis, thrombosis, and vascular biology
Issue Date:
Jul-2015
URI:
http://hdl.handle.net/11287/618031
DOI:
10.1161/ATVBAHA.115.305631
PubMed ID:
25953645
Additional Links:
http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=25953645
Note:
This article is freely available online. Click on the 'Additional Link' above to access the full-text via the publisher's site.
Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
en
ISSN:
1524-4636
Appears in Collections:
2015 RD&E publications; Stroke; Cardiology; Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGoncalves, I.en
dc.contributor.authorBengtsson, E.en
dc.contributor.authorColhoun, H. M.en
dc.contributor.authorShore, Angelaen
dc.contributor.authorPalombo, C.en
dc.contributor.authorNatali, A.en
dc.contributor.authorEdsfeldt, A.en
dc.contributor.authorDunér, P.en
dc.contributor.authorFredrikson, G. N.en
dc.contributor.authorBjörkbacka, H.en
dc.contributor.authorÖstling, G.en
dc.contributor.authorAizawa, Kunihikoen
dc.contributor.authorCasanova, Francescoen
dc.contributor.authorPersson, M.en
dc.contributor.authorGooding, Kimen
dc.contributor.authorStrain, Daviden
dc.contributor.authorKhan, F.en
dc.contributor.authorLooker, H. C.en
dc.contributor.authorAdams, F.en
dc.contributor.authorBelch, J.en
dc.contributor.authorPinnoli, S.en
dc.contributor.authorVenturi, E.en
dc.contributor.authorKozakova, M.en
dc.contributor.authorGan, L.-M.en
dc.contributor.authorSchnecke, V.en
dc.contributor.authorNilsson, J.en
dc.date.accessioned2016-08-08T13:56:01Z-
dc.date.available2016-08-08T13:56:01Z-
dc.date.issued2015-07-
dc.identifier.citationElevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. 2015, 35 (7):1723-31 Arterioscler. Thromb. Vasc. Biol.en
dc.identifier.issn1524-4636-
dc.identifier.pmid25953645-
dc.identifier.doi10.1161/ATVBAHA.115.305631-
dc.identifier.urihttp://hdl.handle.net/11287/618031-
dc.description.abstractMatrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.en
dc.language.isoenen
dc.publisherAmerican Heart Associationen
dc.relation.urlhttp://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=25953645en
dc.rightsArchived with thanks to Arteriosclerosis, thrombosis, and vascular biologyen
dc.subjectWessex Classification Subject Headings::Cardiologyen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleElevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.en
dc.typeJournal Articleen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalArteriosclerosis, thrombosis, and vascular biologyen
dc.description.noteThis article is freely available online. Click on the 'Additional Link' above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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