New genetic loci link adipose and insulin biology to body fat distribution

2.50
Hdl Handle:
http://hdl.handle.net/11287/618115
Title:
New genetic loci link adipose and insulin biology to body fat distribution
Authors:
Shungin, D. [et al]; Hattersley, Andrew T.; Frayling, Timothy M.
Abstract:
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Citation:
New genetic loci link adipose and insulin biology to body fat distribution. 2015 Nature 518(7538):187-96
Publisher:
Nature
Journal:
Nature
Issue Date:
12-Feb-2015
URI:
http://hdl.handle.net/11287/618115
DOI:
10.1038/nature14132
PubMed ID:
25673412
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25673412/
Note:
This article is freely available via PubMed Central. Click on the 'Additional Link' above to access the full-text.
Type:
Journal Article; Meta-Analysis
Language:
en
Appears in Collections:
2015 RD&E publications; Diabetes/Endocrine Services; Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShungin, D. [et al]en
dc.contributor.authorHattersley, Andrew T.en
dc.contributor.authorFrayling, Timothy M.en
dc.date.accessioned2016-08-09T12:10:13Z-
dc.date.available2016-08-09T12:10:13Z-
dc.date.issued2015-02-12-
dc.identifier.citationNew genetic loci link adipose and insulin biology to body fat distribution. 2015 Nature 518(7538):187-96en
dc.identifier.pmid25673412-
dc.identifier.doi10.1038/nature14132-
dc.identifier.urihttp://hdl.handle.net/11287/618115-
dc.description.abstractBody fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.en
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25673412/en
dc.rightsArchived with kind permission of Nature.en
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleNew genetic loci link adipose and insulin biology to body fat distributionen
dc.typeJournal Articleen
dc.typeMeta-Analysisen
dc.identifier.journalNatureen
dc.description.noteThis article is freely available via PubMed Central. Click on the 'Additional Link' above to access the full-text.en
dc.type.versionPublisheden

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