Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.

2.50
Hdl Handle:
http://hdl.handle.net/11287/618199
Title:
Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.
Authors:
Shi, Y.; Avatapalle, H. B.; Skae, M. S.; Padidela, R.; Newbould, M.; Rigby, L.; Flanagan, Sarah; Ellard, Sian ( 0000-0002-7620-5526 ) ; Rahier, J.; Clayton, P. E.; Dunne, M. J.; Banerjee, I.; Cosgrove, K. E.
Abstract:
Congenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.
Citation:
Increased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects. 2015, 166 (1):191-4 J. Pediatr.
Publisher:
Elsevier
Journal:
The Journal of Pediatrics
Issue Date:
Jan-2015
URI:
http://hdl.handle.net/11287/618199
DOI:
10.1016/j.jpeds.2014.09.019
PubMed ID:
25444530
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0022-3476(14)00847-6
Note:
This article is freely available via Open Access, click on the 'Additional Link' above to access the full text via the publisher's site.
Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
en
ISSN:
1097-6833
Appears in Collections:
2015 RD&E publications; Molecular Genetics; Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShi, Y.en
dc.contributor.authorAvatapalle, H. B.en
dc.contributor.authorSkae, M. S.en
dc.contributor.authorPadidela, R.en
dc.contributor.authorNewbould, M.en
dc.contributor.authorRigby, L.en
dc.contributor.authorFlanagan, Sarahen
dc.contributor.authorEllard, Sianen
dc.contributor.authorRahier, J.en
dc.contributor.authorClayton, P. E.en
dc.contributor.authorDunne, M. J.en
dc.contributor.authorBanerjee, I.en
dc.contributor.authorCosgrove, K. E.en
dc.date.accessioned2016-08-10T10:29:17Z-
dc.date.available2016-08-10T10:29:17Z-
dc.date.issued2015-01-
dc.identifier.citationIncreased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects. 2015, 166 (1):191-4 J. Pediatr.en
dc.identifier.issn1097-6833-
dc.identifier.pmid25444530-
dc.identifier.doi10.1016/j.jpeds.2014.09.019-
dc.identifier.urihttp://hdl.handle.net/11287/618199-
dc.description.abstractCongenital hyperinsulinism causes profound hypoglycemia, which may persist or resolve spontaneously. Among 13 children with congenital hyperinsulinism, elevated incretin hormone concentrations were detected in 2 with atypical, persistent disease. We suggest that incretin biomarkers may identify these patients, and that elevated hormone levels may contribute to their pathophysiology.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0022-3476(14)00847-6en
dc.rightsArchived with thanks to The Journal of pediatricsen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Endocrinologyen
dc.titleIncreased plasma incretin concentrations identifies a subset of patients with persistent congenital hyperinsulinism without KATP channel gene defects.en
dc.typeJournal Articleen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalThe Journal of Pediatricsen
dc.description.noteThis article is freely available via Open Access, click on the 'Additional Link' above to access the full text via the publisher's site.en
dc.description.funding098395/Wellcome Trust/United Kingdomen
dc.type.versionPublisheden

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