Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

4.00
Hdl Handle:
http://hdl.handle.net/11287/618281
Title:
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
Authors:
Cousminer, D. L. [et al]; Hattersley, Andrew T.
Abstract:
Little is known about genes regulating male puberty. Further, while many identified pubertal timing variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9 × 10(-9)), a menarche locus tagging a developmental pathway linking earlier puberty with reduced pubertal growth (P = 4.6 × 10(-5)) and short adult stature (p = 7.5 × 10(-6)) in both males and females. Furthermore, our results indicate that a proportion of menarche loci are important for pubertal initiation in both sexes. Consistent with epidemiological correlations between increased prepubertal body mass and earlier pubertal timing in girls, body mass index (BMI)-increasing alleles correlated with earlier breast development. In boys, some BMI-increasing alleles associated with earlier, and others with delayed, sexual development; these genetic results mimic the controversy in epidemiological studies, some of which show opposing correlations between prepubertal BMI and male puberty. Our results contribute to our understanding of the pubertal initiation program in both sexes and indicate that although mechanisms regulating pubertal onset in males and females may largely be shared, the relationship between body mass and pubertal timing in boys may be complex and requires further genetic studies.
Citation:
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. 2014, 23 (16):4452-64 Hum. Mol. Genet.
Publisher:
Oxford Journals
Journal:
Human Molecular Genetics
Issue Date:
15-Aug-2014
URI:
http://hdl.handle.net/11287/618281
DOI:
10.1093/hmg/ddu150
PubMed ID:
24770850
Additional Links:
http://hmg.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=24770850
Note:
This article is freely available from the publisher's site. Click on the 'Additional Link' above to access the full text.
Type:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Language:
en
Description:
Andrew Hattersley is a collaborator on this journal article/project.
ISSN:
1460-2083
Appears in Collections:
2014 RD&E publications; Diabetes/Endocrine Services

Full metadata record

DC FieldValue Language
dc.contributor.authorCousminer, D. L. [et al]en
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2016-08-12T08:51:22Z-
dc.date.available2016-08-12T08:51:22Z-
dc.date.issued2014-08-15-
dc.identifier.citationGenome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. 2014, 23 (16):4452-64 Hum. Mol. Genet.en
dc.identifier.issn1460-2083-
dc.identifier.pmid24770850-
dc.identifier.doi10.1093/hmg/ddu150-
dc.identifier.urihttp://hdl.handle.net/11287/618281-
dc.descriptionAndrew Hattersley is a collaborator on this journal article/project.en
dc.description.abstractLittle is known about genes regulating male puberty. Further, while many identified pubertal timing variants associate with age at menarche, a late manifestation of puberty, and body mass, little is known about these variants' relationship to pubertal initiation or tempo. To address these questions, we performed genome-wide association meta-analysis in over 11 000 European samples with data on early pubertal traits, male genital and female breast development, measured by the Tanner scale. We report the first genome-wide significant locus for male sexual development upstream of myocardin-like 2 (MKL2) (P = 8.9 × 10(-9)), a menarche locus tagging a developmental pathway linking earlier puberty with reduced pubertal growth (P = 4.6 × 10(-5)) and short adult stature (p = 7.5 × 10(-6)) in both males and females. Furthermore, our results indicate that a proportion of menarche loci are important for pubertal initiation in both sexes. Consistent with epidemiological correlations between increased prepubertal body mass and earlier pubertal timing in girls, body mass index (BMI)-increasing alleles correlated with earlier breast development. In boys, some BMI-increasing alleles associated with earlier, and others with delayed, sexual development; these genetic results mimic the controversy in epidemiological studies, some of which show opposing correlations between prepubertal BMI and male puberty. Our results contribute to our understanding of the pubertal initiation program in both sexes and indicate that although mechanisms regulating pubertal onset in males and females may largely be shared, the relationship between body mass and pubertal timing in boys may be complex and requires further genetic studies.en
dc.language.isoenen
dc.publisherOxford Journalsen
dc.relation.urlhttp://hmg.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=24770850en
dc.rightsArchived with thanks to Human molecular geneticsen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleGenome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.en
dc.typeJournal Articleen
dc.typeMeta-Analysisen
dc.typeResearch Support, N.I.H., Extramuralen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalHuman Molecular Geneticsen
dc.description.noteThis article is freely available from the publisher's site. Click on the 'Additional Link' above to access the full text.en
dc.type.versionPublisheden

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