A novel case of a raised testosterone and LH in a young man.

2.50
Hdl Handle:
http://hdl.handle.net/11287/619036
Title:
A novel case of a raised testosterone and LH in a young man.
Authors:
McDonald, Timothy J. ( 0000-0003-3559-6660 ) ; Perry, Mandy ( 0000-0003-4303-2718 ) ; Jones, Angus G.; Donohoe, Mollie; Salzmann, Maurice B.; O'Connor, John D.
Abstract:
A 19 year old male attended his GP with a history of "fluid retention", lack of libido and erectile dysfunction. He was found to have a high serum testosterone, and a raised luteinising hormone. After further investigations, the patient admitted to taking a supplement called ActivaTe Xtreme, obtained from an internet source, to address his low libido. ActivaTe Xtreme contains active ingredients which increase serum testosterone levels by several independent mechanisms that are not associated with luteinising hormone suppression. Urine analyses for synthetic anabolic steroids were negative, and urinary testosterone, epitestosterone and other androgens were normal. This biochemical pattern is not the same as that seen with anabolic steroids (i.e. raised testosterone, suppressed luteinising hormone and abnormal urine steroid profile). The issue of self medication with performance enhancing compounds needs to be carefully considered in order to avoid expensive and invasive investigations, missing an underlying pathology or misdiagnosing a patient. This case also raises the spectre of yet another "performance enhancing" product that may cause difficulty for those trying to ensure that sport remains on a "hormonally" equal basis.
Citation:
A novel case of a raised testosterone and LH in a young man. 2011, 412 (21-22):1999-2001 Clin. Chim. Acta
Publisher:
Elsevier
Journal:
Clinica chimica acta; international journal of clinical chemistry
Issue Date:
9-Oct-2011
URI:
http://hdl.handle.net/11287/619036
DOI:
10.1016/j.cca.2011.06.028
PubMed ID:
21756889
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0009898111003627
Note:
This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.
Type:
Case Report
Language:
en
ISSN:
1873-3492
Appears in Collections:
pre-2014 RD&E publications; Diabetes/Endocrine Services; Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcDonald, Timothy J.en
dc.contributor.authorPerry, Mandyen
dc.contributor.authorJones, Angus G.en
dc.contributor.authorDonohoe, Mollieen
dc.contributor.authorSalzmann, Maurice B.en
dc.contributor.authorO'Connor, John D.en
dc.date.accessioned2016-08-30T09:22:25Z-
dc.date.available2016-08-30T09:22:25Z-
dc.date.issued2011-10-09-
dc.identifier.citationA novel case of a raised testosterone and LH in a young man. 2011, 412 (21-22):1999-2001 Clin. Chim. Actaen
dc.identifier.issn1873-3492-
dc.identifier.pmid21756889-
dc.identifier.doi10.1016/j.cca.2011.06.028-
dc.identifier.urihttp://hdl.handle.net/11287/619036-
dc.description.abstractA 19 year old male attended his GP with a history of "fluid retention", lack of libido and erectile dysfunction. He was found to have a high serum testosterone, and a raised luteinising hormone. After further investigations, the patient admitted to taking a supplement called ActivaTe Xtreme, obtained from an internet source, to address his low libido. ActivaTe Xtreme contains active ingredients which increase serum testosterone levels by several independent mechanisms that are not associated with luteinising hormone suppression. Urine analyses for synthetic anabolic steroids were negative, and urinary testosterone, epitestosterone and other androgens were normal. This biochemical pattern is not the same as that seen with anabolic steroids (i.e. raised testosterone, suppressed luteinising hormone and abnormal urine steroid profile). The issue of self medication with performance enhancing compounds needs to be carefully considered in order to avoid expensive and invasive investigations, missing an underlying pathology or misdiagnosing a patient. This case also raises the spectre of yet another "performance enhancing" product that may cause difficulty for those trying to ensure that sport remains on a "hormonally" equal basis.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0009898111003627en
dc.rightsArchived with thanks to Clinica chimica acta; international journal of clinical chemistryen
dc.subjectWessex Classification Subject Headings::Endocrinologyen
dc.titleA novel case of a raised testosterone and LH in a young man.en
dc.typeCase Reporten
dc.identifier.journalClinica chimica acta; international journal of clinical chemistryen
dc.description.noteThis article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.en
dc.description.fundingDRF-2010-03-72/Department of Health/United Kingdomen
dc.type.versionPublisheden

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