Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.

2.50
Hdl Handle:
http://hdl.handle.net/11287/619208
Title:
Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.
Authors:
Steele, A. M.; Wensley, K. J.; Ellard, Sian ( 0000-0002-7620-5526 ) ; Murphy, R.; Shepherd, Maggie ( 0000-0003-2660-0955 ) ; Colclough, K.; Hattersley, Andrew T.; Shields, Beverley
Abstract:
HaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful for identifying patients with glucokinase (GCK) mutations which cause lifelong persistent fasting hyperglycaemia. We aimed to derive age-related HbA1c reference ranges for these patients to determine how well HbA1c can discriminate patients with a GCK mutation from unaffected family members and young-onset type 1 (T1D) and type 2 diabetes (T2D) and to investigate the proportion of GCK mutation carriers diagnosed with diabetes using HbA1c and/or FPG diagnostic criteria.
Citation:
Use of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies. 2013, 8 (6):e65326 PLoS ONE
Publisher:
PLoS One
Journal:
PloS one
Issue Date:
2013
URI:
http://hdl.handle.net/11287/619208
DOI:
10.1371/journal.pone.0065326
PubMed ID:
23799006
Additional Links:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065326
Note:
This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.
Type:
Observational Study; Research Support, Non-U.S. Gov't
Language:
en
ISSN:
1932-6203
Appears in Collections:
pre-2014 RD&E publications; Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSteele, A. M.en
dc.contributor.authorWensley, K. J.en
dc.contributor.authorEllard, Sianen
dc.contributor.authorMurphy, R.en
dc.contributor.authorShepherd, Maggieen
dc.contributor.authorColclough, K.en
dc.contributor.authorHattersley, Andrew T.en
dc.contributor.authorShields, Beverleyen
dc.date.accessioned2016-09-01T11:34:00Z-
dc.date.available2016-09-01T11:34:00Z-
dc.date.issued2013-
dc.identifier.citationUse of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies. 2013, 8 (6):e65326 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid23799006-
dc.identifier.doi10.1371/journal.pone.0065326-
dc.identifier.urihttp://hdl.handle.net/11287/619208-
dc.description.abstractHaemoglobinA1c (HbA1c) is recommended for diabetes diagnosis but fasting plasma glucose (FPG) has been useful for identifying patients with glucokinase (GCK) mutations which cause lifelong persistent fasting hyperglycaemia. We aimed to derive age-related HbA1c reference ranges for these patients to determine how well HbA1c can discriminate patients with a GCK mutation from unaffected family members and young-onset type 1 (T1D) and type 2 diabetes (T2D) and to investigate the proportion of GCK mutation carriers diagnosed with diabetes using HbA1c and/or FPG diagnostic criteria.en
dc.language.isoenen
dc.publisherPLoS Oneen
dc.relation.urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065326en
dc.rightsArchived with thanks to PloS oneen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleUse of HbA1c in the identification of patients with hyperglycaemia caused by a glucokinase mutation: observational case control studies.en
dc.typeObservational Studyen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalPloS oneen
dc.description.noteThis article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.en
dc.description.funding07/0003473/Diabetes UK/United Kingdom PDA/02/06/098/Department of Health/United Kingdom RDA/03/07/073/Department of Health/United Kingdomen
dc.type.versionPublisheden

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