Urinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-{alpha}/hepatocyte nuclear factor 4-{alpha} maturity-onset diabetes of the young from long-duration type 1 diabetes.

2.50
Hdl Handle:
http://hdl.handle.net/11287/619216
Title:
Urinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-{alpha}/hepatocyte nuclear factor 4-{alpha} maturity-onset diabetes of the young from long-duration type 1 diabetes.
Authors:
Besser, R.; Shepherd, Maggie ( 0000-0003-2660-0955 ) ; McDonald, Timothy J. ( 0000-0003-3559-6660 ) ; Shields, Beverley; Knight, Bridget A.; Ellard, Sian ( 0000-0002-7620-5526 ) ; Hattersley, Andrew T.
Abstract:
Hepatocyte nuclear factor 1-α (HNF1A)/hepatocyte nuclear factor 4-α (HNF4A) maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as type 1 diabetes, and patients are inappropriately treated with insulin. Blood C-peptide can aid in the diagnosis of MODY, but practical reasons limit its widespread use. Urinary C-peptide creatinine ratio (UCPCR), a stable measure of endogenous insulin secretion, is a noninvasive alternative. We aimed to compare stimulated UCPCR in adults with HNF1A/4A MODY, type 1 diabetes, and type 2 diabetes.
Citation:
Urinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-{alpha}/hepatocyte nuclear factor 4-{alpha} maturity-onset diabetes of the young from long-duration type 1 diabetes. 2011, 34 (2):286-91 Diabetes Care
Publisher:
Highwire
Journal:
Diabetes care
Issue Date:
Feb-2011
URI:
http://hdl.handle.net/11287/619216
DOI:
10.2337/dc10-1293
PubMed ID:
21270186
Additional Links:
http://care.diabetesjournals.org/content/34/2/286.long
Note:
RD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.
Type:
Clinical Trial; Research Support, Non-U.S. Gov't
Language:
en
ISSN:
1935-5548
Appears in Collections:
pre-2014 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBesser, R.en
dc.contributor.authorShepherd, Maggieen
dc.contributor.authorMcDonald, Timothy J.en
dc.contributor.authorShields, Beverleyen
dc.contributor.authorKnight, Bridget A.en
dc.contributor.authorEllard, Sianen
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2016-09-01T10:45:01Z-
dc.date.available2016-09-01T10:45:01Z-
dc.date.issued2011-02-
dc.identifier.citationUrinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-{alpha}/hepatocyte nuclear factor 4-{alpha} maturity-onset diabetes of the young from long-duration type 1 diabetes. 2011, 34 (2):286-91 Diabetes Careen
dc.identifier.issn1935-5548-
dc.identifier.pmid21270186-
dc.identifier.doi10.2337/dc10-1293-
dc.identifier.urihttp://hdl.handle.net/11287/619216-
dc.description.abstractHepatocyte nuclear factor 1-α (HNF1A)/hepatocyte nuclear factor 4-α (HNF4A) maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as type 1 diabetes, and patients are inappropriately treated with insulin. Blood C-peptide can aid in the diagnosis of MODY, but practical reasons limit its widespread use. Urinary C-peptide creatinine ratio (UCPCR), a stable measure of endogenous insulin secretion, is a noninvasive alternative. We aimed to compare stimulated UCPCR in adults with HNF1A/4A MODY, type 1 diabetes, and type 2 diabetes.en
dc.language.isoenen
dc.publisherHighwireen
dc.relation.urlhttp://care.diabetesjournals.org/content/34/2/286.longen
dc.rightsArchived with thanks to Diabetes careen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleUrinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-{alpha}/hepatocyte nuclear factor 4-{alpha} maturity-onset diabetes of the young from long-duration type 1 diabetes.en
dc.typeClinical Trialen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalDiabetes careen
dc.description.noteRD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.en
dc.description.fundingPDA/02/06/098/Department of Health/United Kingdomen
dc.type.versionPublisheden
All Items in RD&E Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.