A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients.

2.50
Hdl Handle:
http://hdl.handle.net/11287/619260
Title:
A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients.
Authors:
Shepherd, Maggie ( 0000-0003-2660-0955 ) ; Shields, Beverley; Ellard, Sian ( 0000-0002-7620-5526 ) ; Rubio-Cabezas, O.; Hattersley, Andrew T.
Abstract:
Hepatocyte nuclear factor-1 alpha (HNF1A) gene mutations are the commonest cause of monogenic diabetes, but patients are often misdiagnosed as having Type 1 diabetes and started on insulin treatment. Patients with HNF1A diabetes are particularly sensitive to the glucose-lowering effect of sulphonylureas, which are the pharmacological treatment of choice. We aimed to assess if patients do change from insulin to sulphonylurea treatment when HNF1A diabetes is confirmed and the impact of this treatment change on long-term glycaemic control.
Citation:
A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients. 2009, 26 (4):437-41 Diabet. Med.
Publisher:
Wiley
Journal:
Diabetic medicine : a journal of the British Diabetic Association
Issue Date:
Apr-2009
URI:
http://hdl.handle.net/11287/619260
DOI:
10.1111/j.1464-5491.2009.02690.x
PubMed ID:
19388975
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2009.02690.x/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+3rd+September+2016+at+08.30+BST%2F+03%3A30+EDT%2F+15%3A30+SGT+for+5+hours+and+Sunday+4th+September+at+10%3A00+BST%2F+05%3A00+EST%2F+17%3A00+SGT+for+1+hour++for+essential+maintenance.+Apologies+for+the+inconvenience
Note:
This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.
Type:
Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Language:
en
ISSN:
1464-5491
Appears in Collections:
pre-2014 RD&E publications; pre-2014 RD&E publications; pre-2014 RD&E publications; pre-2014 RD&E publications; Diabetes/Endocrine Services; Clinical Genetics (Peninsula Genetics); Honorary contracts publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShepherd, Maggieen
dc.contributor.authorShields, Beverleyen
dc.contributor.authorEllard, Sianen
dc.contributor.authorRubio-Cabezas, O.en
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2016-09-02T08:57:08Z-
dc.date.accessioned2016-09-02T08:56:47Z-
dc.date.available2016-09-02T08:57:08Z-
dc.date.available2016-09-02T08:56:47Z-
dc.date.issued2009-04-
dc.identifier.citationA genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients. 2009, 26 (4):437-41 Diabet. Med.en
dc.identifier.issn1464-5491-
dc.identifier.pmid19388975-
dc.identifier.doi10.1111/j.1464-5491.2009.02690.x-
dc.identifier.urihttp://hdl.handle.net/11287/619260-
dc.description.abstractHepatocyte nuclear factor-1 alpha (HNF1A) gene mutations are the commonest cause of monogenic diabetes, but patients are often misdiagnosed as having Type 1 diabetes and started on insulin treatment. Patients with HNF1A diabetes are particularly sensitive to the glucose-lowering effect of sulphonylureas, which are the pharmacological treatment of choice. We aimed to assess if patients do change from insulin to sulphonylurea treatment when HNF1A diabetes is confirmed and the impact of this treatment change on long-term glycaemic control.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2009.02690.x/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+3rd+September+2016+at+08.30+BST%2F+03%3A30+EDT%2F+15%3A30+SGT+for+5+hours+and+Sunday+4th+September+at+10%3A00+BST%2F+05%3A00+EST%2F+17%3A00+SGT+for+1+hour++for+essential+maintenance.+Apologies+for+the+inconvenienceen
dc.rightsArchived with thanks to Diabetic medicine : a journal of the British Diabetic Associationen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleA genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patients.en
dc.typeResearch Support, N.I.H., Extramuralen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalDiabetic medicine : a journal of the British Diabetic Associationen
dc.description.noteThis article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.en
dc.description.fundingPDA/02/06/098/Department of Health/United Kingdom Wellcome Trust/United Kingdomen
dc.type.versionPublisheden
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