Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.

2.50
Hdl Handle:
http://hdl.handle.net/11287/619275
Title:
Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.
Authors:
Stride, A.; Ellard, Sian ( 0000-0002-7620-5526 ) ; Clark, P.; Shakespeare, L.; Salzmann, Maurice B.; Shepherd, Maggie ( 0000-0003-2660-0955 ) ; Hattersley, Andrew T.
Abstract:
Patients with diabetes due to hepatocyte nuclear factor (HNF)-1alpha mutations have beta-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. It is uncertain how many of these features precede the development of diabetes. The aim of our study was to test for these characteristics in young nondiabetic HNF-1alpha mutation carriers.
Citation:
Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers. 2005, 28 (7):1751-6 Diabetes Care
Publisher:
Highwire
Journal:
Diabetes care
Issue Date:
Jul-2005
URI:
http://hdl.handle.net/11287/619275
PubMed ID:
15983330
Additional Links:
http://care.diabetesjournals.org/content/28/7/1751.long
Note:
RD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.
Type:
Research Support, Non-U.S. Gov't
Language:
en
ISSN:
0149-5992
Sponsors:
Wellcome Trust/United Kingdom
Appears in Collections:
pre-2014 RD&E publications; Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology); Clinical Genetics (Peninsula Genetics)

Full metadata record

DC FieldValue Language
dc.contributor.authorStride, A.en
dc.contributor.authorEllard, Sianen
dc.contributor.authorClark, P.en
dc.contributor.authorShakespeare, L.en
dc.contributor.authorSalzmann, Maurice B.en
dc.contributor.authorShepherd, Maggieen
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2016-09-02T10:29:10Z-
dc.date.available2016-09-02T10:29:10Z-
dc.date.issued2005-07-
dc.identifier.citationBeta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers. 2005, 28 (7):1751-6 Diabetes Careen
dc.identifier.issn0149-5992-
dc.identifier.pmid15983330-
dc.identifier.urihttp://hdl.handle.net/11287/619275-
dc.description.abstractPatients with diabetes due to hepatocyte nuclear factor (HNF)-1alpha mutations have beta-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. It is uncertain how many of these features precede the development of diabetes. The aim of our study was to test for these characteristics in young nondiabetic HNF-1alpha mutation carriers.en
dc.description.sponsorshipWellcome Trust/United Kingdomen
dc.language.isoenen
dc.publisherHighwireen
dc.relation.urlhttp://care.diabetesjournals.org/content/28/7/1751.longen
dc.rightsArchived with thanks to Diabetes careen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleBeta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers.en
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalDiabetes careen
dc.description.noteRD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.en
dc.type.versionPublisheden

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