Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers.

2.50
Hdl Handle:
http://hdl.handle.net/11287/619510
Title:
Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers.
Authors:
Stride, A.; Shepherd, Maggie ( 0000-0003-2660-0955 ) ; Frayling, T. M.; Bulman, Mike P; Ellard, Sian ( 0000-0002-7620-5526 ) ; Hattersley, Andrew T.
Abstract:
In animals, experimentally induced maternal hyperglycemia during pregnancy results in hyperglycemic offspring. Similarly, Pima Indian offspring with mothers who are diabetic at the time of pregnancy have increased risk of early-onset diabetes. We hypothesized that exposure to hyperglycemia in utero would decrease the age at diagnosis of diabetes in patients with maturity-onset diabetes of the young (MODY) due to a mutation in the hepatocyte nuclear factor 1alpha (HNF-1alpha) gene.
Citation:
Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers. 2002, 25 (12):2287-91 Diabetes Care
Publisher:
Highwire
Journal:
Diabetes care
Issue Date:
Dec-2002
URI:
http://hdl.handle.net/11287/619510
PubMed ID:
12453975
Additional Links:
http://care.diabetesjournals.org/content/25/12/2287.long
Note:
RD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.
Type:
Research Support, Non-U.S. Gov't
Language:
en
ISSN:
0149-5992
Appears in Collections:
pre-2014 RD&E publications; Diabetes/Endocrine Services; Clinical Genetics (Peninsula Genetics)

Full metadata record

DC FieldValue Language
dc.contributor.authorStride, A.en
dc.contributor.authorShepherd, Maggieen
dc.contributor.authorFrayling, T. M.en
dc.contributor.authorBulman, Mike Pen
dc.contributor.authorEllard, Sianen
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2016-09-02T11:04:50Z-
dc.date.available2016-09-02T11:04:50Z-
dc.date.issued2002-12-
dc.identifier.citationIntrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers. 2002, 25 (12):2287-91 Diabetes Careen
dc.identifier.issn0149-5992-
dc.identifier.pmid12453975-
dc.identifier.urihttp://hdl.handle.net/11287/619510-
dc.description.abstractIn animals, experimentally induced maternal hyperglycemia during pregnancy results in hyperglycemic offspring. Similarly, Pima Indian offspring with mothers who are diabetic at the time of pregnancy have increased risk of early-onset diabetes. We hypothesized that exposure to hyperglycemia in utero would decrease the age at diagnosis of diabetes in patients with maturity-onset diabetes of the young (MODY) due to a mutation in the hepatocyte nuclear factor 1alpha (HNF-1alpha) gene.en
dc.language.isoenen
dc.publisherHighwireen
dc.relation.urlhttp://care.diabetesjournals.org/content/25/12/2287.longen
dc.rightsArchived with thanks to Diabetes careen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleIntrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers.en
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalDiabetes careen
dc.description.noteRD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.en
dc.type.versionPublisheden

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