Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

2.50
Hdl Handle:
http://hdl.handle.net/11287/620023
Title:
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Authors:
Surendran, P [et al]; Yaghootkar, Hanieh
Abstract:
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
Citation:
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics. 2016 Oct;48(10):1151-61
Publisher:
Nature
Journal:
Nature Genetics
Issue Date:
12-Sep-2016
URI:
http://hdl.handle.net/11287/620023
DOI:
10.1038/ng.3654
PubMed ID:
27618447
Type:
Journal Article
Language:
en
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSurendran, P [et al]en
dc.contributor.authorYaghootkar, Haniehen
dc.date.accessioned2016-09-21T14:04:02Z-
dc.date.available2016-09-21T14:04:02Z-
dc.date.issued2016-09-12-
dc.identifier.citationTrans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics. 2016 Oct;48(10):1151-61en
dc.identifier.pmid27618447-
dc.identifier.doi10.1038/ng.3654-
dc.identifier.urihttp://hdl.handle.net/11287/620023-
dc.description.abstractHigh blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.en
dc.language.isoenen
dc.publisherNatureen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleTrans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertensionen
dc.typeJournal Articleen
dc.identifier.journalNature Geneticsen
dc.type.versionIn press (epub ahead of print)en

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