Tiotropium in asthma: what is the evidence and how does it fit in?

2.50
Hdl Handle:
http://hdl.handle.net/11287/620040
Title:
Tiotropium in asthma: what is the evidence and how does it fit in?
Authors:
Halpin, David M
Abstract:
Despite current therapeutic approaches asthma remains uncontrolled in a significant proportion of patients. Short-acting anticholinergic bronchodilators have a very long history of use in asthma, and recent data confirms the importance of acetylcholine as both a bronchoconstrictor and as a regulator of inflammation and remodeling in the lungs. Data from a comprehensive clinical trial programme, as well as use in primary care, show the efficacy and safety of tiotropium in adults with mild to moderate asthma when it is added to ICS and in severe asthma when it is added to high doses of ICS plus LABA, as well as in adolescents. Tiotropium is cost effective and its benefits are not restricted to particular phenotypes, making it a useful addition to the therapeutic options recommended by the Global Initiative for Asthma (GINA) for people with poorly controlled asthma at steps 4 & 5.
Citation:
Tiotropium in asthma: what is the evidence and how does it fit in? 2016, 9 (1):29 World Allergy Organ J
Publisher:
BioMed Central
Journal:
The World Allergy Organization journal
Issue Date:
14-Sep-2016
URI:
http://hdl.handle.net/11287/620040
DOI:
10.1186/s40413-016-0119-y
PubMed ID:
27679681
Additional Links:
http://waojournal.biomedcentral.com/articles/10.1186/s40413-016-0119-y
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article; Systematic review
Language:
en
Appears in Collections:
Respiratory Medicine; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHalpin, David Men
dc.date.accessioned2016-10-19T09:06:35Z-
dc.date.available2016-10-19T09:06:35Z-
dc.date.issued2016-09-14-
dc.identifier.citationTiotropium in asthma: what is the evidence and how does it fit in? 2016, 9 (1):29 World Allergy Organ Jen
dc.identifier.pmid27679681-
dc.identifier.doi10.1186/s40413-016-0119-y-
dc.identifier.urihttp://hdl.handle.net/11287/620040-
dc.description.abstractDespite current therapeutic approaches asthma remains uncontrolled in a significant proportion of patients. Short-acting anticholinergic bronchodilators have a very long history of use in asthma, and recent data confirms the importance of acetylcholine as both a bronchoconstrictor and as a regulator of inflammation and remodeling in the lungs. Data from a comprehensive clinical trial programme, as well as use in primary care, show the efficacy and safety of tiotropium in adults with mild to moderate asthma when it is added to ICS and in severe asthma when it is added to high doses of ICS plus LABA, as well as in adolescents. Tiotropium is cost effective and its benefits are not restricted to particular phenotypes, making it a useful addition to the therapeutic options recommended by the Global Initiative for Asthma (GINA) for people with poorly controlled asthma at steps 4 & 5.en
dc.languageENG-
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://waojournal.biomedcentral.com/articles/10.1186/s40413-016-0119-yen
dc.rightsArchived with thanks to The World Allergy Organization journal. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectWessex Classification Subject Headings::Respiratory medicineen
dc.titleTiotropium in asthma: what is the evidence and how does it fit in?en
dc.typeJournal Articleen
dc.typeSystematic reviewen
dc.identifier.journalThe World Allergy Organization journalen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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