Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620074
Title:
Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain.
Authors:
Smith, A. R.; Smith, R. G.; Condliffe, D.; Hannon, E.; Schalkwyk, L.; Mill, Jonathan; Lunnon, K.
Abstract:
Although mutations within the TREM2 gene have been robustly associated with Alzheimer's disease, it is not known whether alterations in the regulation of this gene are also involved in pathogenesis. Here, we present data demonstrating increased DNA methylation in the superior temporal gyrus in Alzheimer's disease brain at a CpG site located 289 bp upstream of the transcription start site of the TREM2 gene in 3 independent study cohorts using 2 different technologies (Illumina Infinium 450K methylation beadchip and pyrosequencing). A meta-analysis across all 3 cohorts reveals consistent AD-associated hypermethylation (p = 3.47E-08). This study highlights that extending genetic studies of TREM2 in AD to investigate epigenetic changes may nominate additional mechanisms by which disruption to this gene increases risk.
Citation:
Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. 2016, 47:35-40 Neurobiol. Aging
Publisher:
Elsevier
Journal:
Neurobiology of aging
Issue Date:
Nov-2016
URI:
http://hdl.handle.net/11287/620074
DOI:
10.1016/j.neurobiolaging.2016.07.008
PubMed ID:
27522519
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0197-4580(16)30138-5
Type:
Journal Article
Language:
en
ISSN:
1558-1497
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSmith, A. R.en
dc.contributor.authorSmith, R. G.en
dc.contributor.authorCondliffe, D.en
dc.contributor.authorHannon, E.en
dc.contributor.authorSchalkwyk, L.en
dc.contributor.authorMill, Jonathanen
dc.contributor.authorLunnon, K.en
dc.date.accessioned2016-11-09T12:49:05Z-
dc.date.available2016-11-09T12:49:05Z-
dc.date.issued2016-11-
dc.identifier.citationIncreased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. 2016, 47:35-40 Neurobiol. Agingen
dc.identifier.issn1558-1497-
dc.identifier.pmid27522519-
dc.identifier.doi10.1016/j.neurobiolaging.2016.07.008-
dc.identifier.urihttp://hdl.handle.net/11287/620074-
dc.description.abstractAlthough mutations within the TREM2 gene have been robustly associated with Alzheimer's disease, it is not known whether alterations in the regulation of this gene are also involved in pathogenesis. Here, we present data demonstrating increased DNA methylation in the superior temporal gyrus in Alzheimer's disease brain at a CpG site located 289 bp upstream of the transcription start site of the TREM2 gene in 3 independent study cohorts using 2 different technologies (Illumina Infinium 450K methylation beadchip and pyrosequencing). A meta-analysis across all 3 cohorts reveals consistent AD-associated hypermethylation (p = 3.47E-08). This study highlights that extending genetic studies of TREM2 in AD to investigate epigenetic changes may nominate additional mechanisms by which disruption to this gene increases risk.en
dc.languageENG-
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0197-4580(16)30138-5en
dc.rightsArchived with thanks to Neurobiology of agingen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleIncreased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain.en
dc.typeJournal Articleen
dc.identifier.journalNeurobiology of agingen
dc.type.versionPublisheden

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