Prognostic biomarkers to identify patients destined to develop severe Crohn's disease who may benefit from early biological therapy: protocol for a systematic review, meta-analysis and external validation.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620113
Title:
Prognostic biomarkers to identify patients destined to develop severe Crohn's disease who may benefit from early biological therapy: protocol for a systematic review, meta-analysis and external validation.
Authors:
Halligan, S.; Boone, D.; Bhatnagar, G.; Ahmad, Tariq; Bloom, S.; Rodriguez-Justo, M.; Taylor, S. A.; Mallett, S.
Abstract:
It is believed increasingly that patients with severe Crohn's disease are best treated early with biological therapy, which may ameliorate subsequent disease course and diminish long-term complications. However, we cannot predict currently which new presentations of Crohn's disease are destined to develop severe disease so treatment cannot be targeted to the most appropriate patients. Accordingly, via systematic review and meta-analysis we aim to identify if biomarkers of disease activity are able to predict development of severe disease.
Citation:
Prognostic biomarkers to identify patients destined to develop severe Crohn's disease who may benefit from early biological therapy: protocol for a systematic review, meta-analysis and external validation. 2016, 5 (1):206 Syst Rev
Publisher:
BioMed Central
Journal:
Systematic Reviews
Issue Date:
1-Dec-2016
URI:
http://hdl.handle.net/11287/620113
DOI:
10.1186/s13643-016-0383-5
PubMed ID:
27903285
Additional Links:
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0383-5
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
2046-4053
Appears in Collections:
Gastroenterology; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHalligan, S.en
dc.contributor.authorBoone, D.en
dc.contributor.authorBhatnagar, G.en
dc.contributor.authorAhmad, Tariqen
dc.contributor.authorBloom, S.en
dc.contributor.authorRodriguez-Justo, M.en
dc.contributor.authorTaylor, S. A.en
dc.contributor.authorMallett, S.en
dc.date.accessioned2016-12-05T11:06:10Z-
dc.date.available2016-12-05T11:06:10Z-
dc.date.issued2016-12-01-
dc.identifier.citationPrognostic biomarkers to identify patients destined to develop severe Crohn's disease who may benefit from early biological therapy: protocol for a systematic review, meta-analysis and external validation. 2016, 5 (1):206 Syst Reven
dc.identifier.issn2046-4053-
dc.identifier.pmid27903285-
dc.identifier.doi10.1186/s13643-016-0383-5-
dc.identifier.urihttp://hdl.handle.net/11287/620113-
dc.description.abstractIt is believed increasingly that patients with severe Crohn's disease are best treated early with biological therapy, which may ameliorate subsequent disease course and diminish long-term complications. However, we cannot predict currently which new presentations of Crohn's disease are destined to develop severe disease so treatment cannot be targeted to the most appropriate patients. Accordingly, via systematic review and meta-analysis we aim to identify if biomarkers of disease activity are able to predict development of severe disease.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttps://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0383-5en
dc.rightsArchived with thanks to Systematic Reviews.This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectWessex Classification Subject Headings::Gastroenterologyen
dc.titlePrognostic biomarkers to identify patients destined to develop severe Crohn's disease who may benefit from early biological therapy: protocol for a systematic review, meta-analysis and external validation.en
dc.typeJournal Articleen
dc.identifier.journalSystematic Reviewsen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden
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