Effects of Exendin-4 on human adipose tissue inflammation and ECM remodelling

2.50
Hdl Handle:
http://hdl.handle.net/11287/620119
Title:
Effects of Exendin-4 on human adipose tissue inflammation and ECM remodelling
Authors:
Pastel, E; Joshi, S; Knight, Bridget A.; Liversedge, Neil H.; Ward, R; Kos, K
Abstract:
Subjects with type-2 diabetes are typically obese with dysfunctional adipose tissue (AT). Glucagon-like peptide-1 (GLP-1) analogues are routinely used to improve glycaemia. Although, they also aid weight loss that improves AT function, their direct effect on AT function is unclear. To explore GLP-1 analogues’ influence on human AT’s cytokine and extracellular matrix (ECM) regulation, we therefore obtained and treated omental (OMAT) and subcutaneous (SCAT) AT samples with Exendin-4, an agonist of the GLP-1 receptor (GLP-1R)
Citation:
Effects of Exendin-4 on human adipose tissue inflammation and ECM remodelling 2016, 6 (12):e235 Nutrition & Diabetes
Publisher:
Nature
Journal:
Nutrition & Diabetes
Issue Date:
12-Dec-2016
URI:
http://hdl.handle.net/11287/620119
DOI:
10.1038/nutd.2016.44
Additional Links:
http://www.nature.com/doifinder/10.1038/nutd.2016.44
Type:
Journal Article
Language:
en
ISSN:
2044-4052
Appears in Collections:
Diabetes/Endocrine Services; Obstetrics, Gynaecology & Maternity Services; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPastel, Een
dc.contributor.authorJoshi, Sen
dc.contributor.authorKnight, Bridget A.en
dc.contributor.authorLiversedge, Neil H.en
dc.contributor.authorWard, Ren
dc.contributor.authorKos, Ken
dc.date.accessioned2016-12-21T10:31:10Z-
dc.date.available2016-12-21T10:31:10Z-
dc.date.issued2016-12-12-
dc.identifier.citationEffects of Exendin-4 on human adipose tissue inflammation and ECM remodelling 2016, 6 (12):e235 Nutrition & Diabetesen
dc.identifier.issn2044-4052-
dc.identifier.doi10.1038/nutd.2016.44-
dc.identifier.urihttp://hdl.handle.net/11287/620119-
dc.description.abstractSubjects with type-2 diabetes are typically obese with dysfunctional adipose tissue (AT). Glucagon-like peptide-1 (GLP-1) analogues are routinely used to improve glycaemia. Although, they also aid weight loss that improves AT function, their direct effect on AT function is unclear. To explore GLP-1 analogues’ influence on human AT’s cytokine and extracellular matrix (ECM) regulation, we therefore obtained and treated omental (OMAT) and subcutaneous (SCAT) AT samples with Exendin-4, an agonist of the GLP-1 receptor (GLP-1R)en
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttp://www.nature.com/doifinder/10.1038/nutd.2016.44en
dc.rightsArchived with thanks to Nutrition & Diabetes. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectWessex Classification Subject Headings::Diseases & disorders of systemic, metabolic or environmental origin::Diet & nutritionen
dc.titleEffects of Exendin-4 on human adipose tissue inflammation and ECM remodellingen
dc.typeJournal Articleen
dc.identifier.journalNutrition & Diabetesen
dc.type.versionPublisheden
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