Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts

2.50
Hdl Handle:
http://hdl.handle.net/11287/620127
Title:
Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts
Authors:
Huang, W-C; Lin, J-Y; Wallace, Christopher G ( 0000-0003-1897-9520 ) ; Wei, F-C; Liao, S-K
Abstract:
Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions.
Citation:
Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts 2012, 2012:1 Clinical and Developmental Immunology
Publisher:
Hindawi
Journal:
Clinical and Developmental Immunology
Issue Date:
Oct-2012
URI:
http://hdl.handle.net/11287/620127
DOI:
10.1155/2012/107901
Additional Links:
http://www.hindawi.com/journals/jir/2012/107901/
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
en
ISSN:
1740-2522; 1740-2530
Appears in Collections:
Plastic & Reconstructive Surgery; pre-2014 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHuang, W-Cen
dc.contributor.authorLin, J-Yen
dc.contributor.authorWallace, Christopher Gen
dc.contributor.authorWei, F-Cen
dc.contributor.authorLiao, S-Ken
dc.date.accessioned2017-01-04T15:48:30Z-
dc.date.available2017-01-04T15:48:30Z-
dc.date.issued2012-10-
dc.identifier.citationImproving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts 2012, 2012:1 Clinical and Developmental Immunologyen
dc.identifier.issn1740-2522-
dc.identifier.issn1740-2530-
dc.identifier.doi10.1155/2012/107901-
dc.identifier.urihttp://hdl.handle.net/11287/620127-
dc.description.abstractAlthough vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. Recently it has been demonstrated that VCAs incorporating a vascularized long bone in a rat model provide concurrent vascularized bone marrow transplantation that, itself, functions to establish hematopoietic chimerism and donor-specific tolerance following non-myeloablative conditioning of recipients. Advances such as this, which aim to improve the safety profile of tolerance induction, will help usher in an era of wider clinical VCA application for nonlife-saving reconstructions.en
dc.language.isoenen
dc.publisherHindawien
dc.relation.urlhttp://www.hindawi.com/journals/jir/2012/107901/en
dc.rightsArchived with thanks to Clinical and Developmental Immunologyen
dc.subjectWessex Classification Subject Headings::Surgery::Plastic surgeryen
dc.titleImproving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allograftsen
dc.typeJournal Articleen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalClinical and Developmental Immunologyen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden
dc.contributor.institutionDivision of Plastic and Reconstructive Surgery, Tzu Chi General Hospital, New Taipei 231, Taiwan-
dc.contributor.institutionGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan-
dc.contributor.institutionDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan-
dc.contributor.institutionDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan-
dc.contributor.institutionGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan-
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