Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning

2.50
Hdl Handle:
http://hdl.handle.net/11287/620177
Title:
Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning
Authors:
Lin, J-Y; Tsai, F-C; Wallace, Christopher G ( 0000-0003-1897-9520 ) ; Huang, W-C; Wei, F-C; Liao, S-K
Abstract:
We demonstrate herein that combination treatment with regulatory T cells (Tregs) and vascularized bone marrow transplantation (VBMT) can achieve stable mixed chimerism and long-term transplantation tolerance to vascularized composite allografts (VCA) without requiring cytoreductive recipient conditioning in rats. An appreciable number of Tregs of recipient origin was shown at the interface between recipient and transplanted VCA tissues, implicating a significant role for Tregs in protecting VCA from rejection. This cytoreduction-free protocol using co-treatment with Tregs and VBMT warrants further investigation toward potential clinical application for VCA transplantation.
Citation:
Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning 2014, 4 (1):20 Chimerism
Publisher:
Taylor & Francis
Journal:
Chimerism
Issue Date:
2013
URI:
http://hdl.handle.net/11287/620177
DOI:
10.4161/chim.23349
Additional Links:
http://www.tandfonline.com/doi/abs/10.4161/chim.23349; https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23712382/
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
ISSN:
1938-1956; 1938-1964
Appears in Collections:
Plastic & Reconstructive Surgery; pre-2014 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLin, J-Yen
dc.contributor.authorTsai, F-Cen
dc.contributor.authorWallace, Christopher Gen
dc.contributor.authorHuang, W-Cen
dc.contributor.authorWei, F-Cen
dc.contributor.authorLiao, S-Ken
dc.date.accessioned2017-01-18T13:27:35Z-
dc.date.available2017-01-18T13:27:35Z-
dc.date.issued2013-
dc.identifier.citationCombined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning 2014, 4 (1):20 Chimerismen
dc.identifier.issn1938-1956-
dc.identifier.issn1938-1964-
dc.identifier.doi10.4161/chim.23349-
dc.identifier.urihttp://hdl.handle.net/11287/620177-
dc.description.abstractWe demonstrate herein that combination treatment with regulatory T cells (Tregs) and vascularized bone marrow transplantation (VBMT) can achieve stable mixed chimerism and long-term transplantation tolerance to vascularized composite allografts (VCA) without requiring cytoreductive recipient conditioning in rats. An appreciable number of Tregs of recipient origin was shown at the interface between recipient and transplanted VCA tissues, implicating a significant role for Tregs in protecting VCA from rejection. This cytoreduction-free protocol using co-treatment with Tregs and VBMT warrants further investigation toward potential clinical application for VCA transplantation.en
dc.publisherTaylor & Francisen
dc.relation.urlhttp://www.tandfonline.com/doi/abs/10.4161/chim.23349en
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23712382/en
dc.rightsArchived with thanks to Chimerismen
dc.subjectWessex Classification Subject Headings::Microbiology. Immunologyen
dc.titleCombined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning-
dc.typeJournal Articleen
dc.identifier.journalChimerismen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden
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