Collapsed methylation quantitative trait loci analysis for low frequency and rare variants.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620261
Title:
Collapsed methylation quantitative trait loci analysis for low frequency and rare variants.
Authors:
Richardson, T.; Shihab, H.A.; Hemani, G.; Zheng, J.; Hannon, Eilis; Mill, Jonathan; Carnero-Montoro, E.; Bell, J.; Lyttleton, O.; McArdle, W.; Ring, S. M.; Rodriguez, S.; Campbell, C.; Smith, G.; Relton, C.L.; Timpson, N.J.; Gaunt, T.R.
Abstract:
Single variant approaches have been successful in identifying DNA methylation quantitative trait loci (mQTL), although as with complex traits they lack the statistical power to identify the effects from rare genetic variants. We have undertaken extensive analyses to identify regions of low frequency and rare variants that are associated with DNA methylation levels.
Citation:
Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. 2016, 25 (19):4339-4349 Hum. Mol. Genet.
Publisher:
Oxford Academic
Journal:
Human molecular genetics
Issue Date:
1-Oct-2016
URI:
http://hdl.handle.net/11287/620261
DOI:
10.1093/hmg/ddw283
PubMed ID:
27559110
Additional Links:
https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/ddw283
Note:
This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.
Type:
Journal Article
Language:
en
ISSN:
1460-2083
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRichardson, T.en
dc.contributor.authorShihab, H.A.en
dc.contributor.authorHemani, G.en
dc.contributor.authorZheng, J.en
dc.contributor.authorHannon, Eilisen
dc.contributor.authorMill, Jonathanen
dc.contributor.authorCarnero-Montoro, E.en
dc.contributor.authorBell, J.en
dc.contributor.authorLyttleton, O.en
dc.contributor.authorMcArdle, W.en
dc.contributor.authorRing, S. M.en
dc.contributor.authorRodriguez, S.en
dc.contributor.authorCampbell, C.en
dc.contributor.authorSmith, G.en
dc.contributor.authorRelton, C.L.en
dc.contributor.authorTimpson, N.J.en
dc.contributor.authorGaunt, T.R.en
dc.date.accessioned2017-03-10T13:46:38Z-
dc.date.available2017-03-10T13:46:38Z-
dc.date.issued2016-10-01-
dc.identifier.citationCollapsed methylation quantitative trait loci analysis for low frequency and rare variants. 2016, 25 (19):4339-4349 Hum. Mol. Genet.en
dc.identifier.issn1460-2083-
dc.identifier.pmid27559110-
dc.identifier.doi10.1093/hmg/ddw283-
dc.identifier.urihttp://hdl.handle.net/11287/620261-
dc.description.abstractSingle variant approaches have been successful in identifying DNA methylation quantitative trait loci (mQTL), although as with complex traits they lack the statistical power to identify the effects from rare genetic variants. We have undertaken extensive analyses to identify regions of low frequency and rare variants that are associated with DNA methylation levels.en
dc.language.isoenen
dc.publisherOxford Academicen
dc.relation.urlhttps://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/ddw283en
dc.rightsArchived with thanks to Human molecular geneticsen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleCollapsed methylation quantitative trait loci analysis for low frequency and rare variants.en
dc.typeJournal Articleen
dc.identifier.journalHuman molecular geneticsen
dc.description.noteThis article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.en
dc.description.funding102215/Wellcome Trust/United Kingdom MC_PC_15018/Medical Research Council/United Kingdom MC_UU_12013/1/Medical Research Council/United Kingdomen
dc.type.versionPublisheden

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