DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620262
Title:
DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis.
Authors:
McDermott, E.; Ryan, E.J.; Tosetto, M.; Gibson, D.; Burrage, Joe; Keegan, D.; Byrne, K.; Crowe, E.; Sexton, G.; Malone, K.; Harris, R.A.; Kellermayer, R.; Mill, Jonathan; Cullen, G.; Doherty, G.A.; Mulcahy, H.; Murphy, Therese M.
Abstract:
Inflammatory bowel diseases (IBDs) are heterogeneous disorders with complex aetiology. Quantitative genetic studies suggest that only a small proportion of the disease variance observed in IBD is accounted for by genetic variation, indicating a potential role for differential epigenetic regulation in disease aetiology. The aim of this study was to assess genome-wide DNA methylation changes specifically associated with ulcerative colitis (UC), Crohn's disease (CD) and IBD activity.
Citation:
DNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. 2016, 10 (1):77-86 J Crohns Colitis
Publisher:
Oxford Academic
Journal:
Journal of Crohn's & colitis
Issue Date:
Jan-2016
URI:
http://hdl.handle.net/11287/620262
DOI:
10.1093/ecco-jcc/jjv176
PubMed ID:
26419460
Additional Links:
https://academic.oup.com/ecco-jcc/article-lookup/doi/10.1093/ecco-jcc/jjv176
Note:
This article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.
Type:
Comparative Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Language:
en
ISSN:
1876-4479
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMcDermott, E.en
dc.contributor.authorRyan, E.J.en
dc.contributor.authorTosetto, M.en
dc.contributor.authorGibson, D.en
dc.contributor.authorBurrage, Joeen
dc.contributor.authorKeegan, D.en
dc.contributor.authorByrne, K.en
dc.contributor.authorCrowe, E.en
dc.contributor.authorSexton, G.en
dc.contributor.authorMalone, K.en
dc.contributor.authorHarris, R.A.en
dc.contributor.authorKellermayer, R.en
dc.contributor.authorMill, Jonathanen
dc.contributor.authorCullen, G.en
dc.contributor.authorDoherty, G.A.en
dc.contributor.authorMulcahy, H.en
dc.contributor.authorMurphy, Therese M.en
dc.date.accessioned2017-03-10T14:02:34Z-
dc.date.available2017-03-10T14:02:34Z-
dc.date.issued2016-01-
dc.identifier.citationDNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis. 2016, 10 (1):77-86 J Crohns Colitisen
dc.identifier.issn1876-4479-
dc.identifier.pmid26419460-
dc.identifier.doi10.1093/ecco-jcc/jjv176-
dc.identifier.urihttp://hdl.handle.net/11287/620262-
dc.description.abstractInflammatory bowel diseases (IBDs) are heterogeneous disorders with complex aetiology. Quantitative genetic studies suggest that only a small proportion of the disease variance observed in IBD is accounted for by genetic variation, indicating a potential role for differential epigenetic regulation in disease aetiology. The aim of this study was to assess genome-wide DNA methylation changes specifically associated with ulcerative colitis (UC), Crohn's disease (CD) and IBD activity.en
dc.language.isoenen
dc.publisherOxford Academicen
dc.relation.urlhttps://academic.oup.com/ecco-jcc/article-lookup/doi/10.1093/ecco-jcc/jjv176en
dc.rightsArchived with thanks to Journal of Crohn's & colitisen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Gastroenterologyen
dc.titleDNA Methylation Profiling in Inflammatory Bowel Disease Provides New Insights into Disease Pathogenesis.en
dc.typeComparative Studyen
dc.typeResearch Support, N.I.H., Extramuralen
dc.typeResearch Support, Non-U.S. Gov'ten
dc.identifier.journalJournal of Crohn's & colitisen
dc.description.noteThis article is freely available via Open Access. Click on the ‘Additional Link’ above to access the full-text from the publisher’s site.en
dc.description.fundingP30 DK56338/DK/NIDDK NIH HHS/United Statesen
dc.type.versionPublisheden

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