Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620264
Title:
Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.
Authors:
Devall, Matthew; Roubroeks, J.; Mill, Jonathan; Weedon, M.; Lunnon, Katie
Abstract:
The field of mitochondrial epigenetics has received increased attention in recent years and changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis. However, current publications have been limited by the use of global or targeted methods of measuring DNA methylation. In this review, we discuss current findings in mitochondrial epigenetics as well as its potential role as a regulator of mitochondria within the brain. Finally, we summarize the current technologies best suited to capturing mtDNA methylation, and how a move towards whole epigenome sequencing of mtDNA may help to advance our current understanding of the field.
Citation:
Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. 2016, 625:47-55 Neurosci. Lett.
Publisher:
Elsevier
Journal:
Neuroscience letters
Issue Date:
20-Jun-2016
URI:
http://hdl.handle.net/11287/620264
DOI:
10.1016/j.neulet.2016.02.013
PubMed ID:
26876477
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0304394016300817
Note:
RD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.
Type:
Systematic review
Language:
en
ISSN:
1872-7972
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDevall, Matthewen
dc.contributor.authorRoubroeks, J.en
dc.contributor.authorMill, Jonathanen
dc.contributor.authorWeedon, M.en
dc.contributor.authorLunnon, Katieen
dc.date.accessioned2017-03-10T15:48:39Z-
dc.date.available2017-03-10T15:48:39Z-
dc.date.issued2016-06-20-
dc.identifier.citationEpigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies. 2016, 625:47-55 Neurosci. Lett.en
dc.identifier.issn1872-7972-
dc.identifier.pmid26876477-
dc.identifier.doi10.1016/j.neulet.2016.02.013-
dc.identifier.urihttp://hdl.handle.net/11287/620264-
dc.description.abstractThe field of mitochondrial epigenetics has received increased attention in recent years and changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis. However, current publications have been limited by the use of global or targeted methods of measuring DNA methylation. In this review, we discuss current findings in mitochondrial epigenetics as well as its potential role as a regulator of mitochondria within the brain. Finally, we summarize the current technologies best suited to capturing mtDNA methylation, and how a move towards whole epigenome sequencing of mtDNA may help to advance our current understanding of the field.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0304394016300817en
dc.rightsArchived with thanks to Neuroscience lettersen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleEpigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.en
dc.typeSystematic reviewen
dc.identifier.journalNeuroscience lettersen
dc.description.noteRD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.en
dc.description.fundingR01 AG036039/AG/NIA NIH HHS/United Statesen
dc.type.versionPublisheden

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