Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620265
Title:
Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability.
Authors:
Cecil, C.A.M.; Smith, Rebecca; Walton, E.; Mill, Jonathan; McCrory, E.; Viding, E.
Abstract:
Childhood maltreatment is a key risk factor for poor mental and physical health. Recently, variation in epigenetic processes, such as DNA methylation, has emerged as a potential pathway mediating this association; yet, the extent to which different forms of maltreatment may be characterized by unique vs shared epigenetic signatures is currently unknown. In this study, we quantified DNA methylation across the genome in buccal epithelial cell samples from a high-risk sample of inner-city youth (n = 124; age = 16-24; 53% female), 68% of whom reported experiencing at least one form of maltreatment while growing up. Our analyses aimed to identify methylomic variation associated with exposure to five major types of childhood maltreatment. We found that: (i) maltreatment types differ in the extent to which they associate with methylomic variation, with physical exposures showing the strongest associations; (ii) many of the identified loci are annotated to genes previously implicated in stress-related outcomes, including psychiatric and physical disorders (e.g. GABBR1, GRIN2D, CACNA2D4, PSEN2); and (iii) based on gene ontology analyses, maltreatment types not only show unique methylation patterns enriched for specific biological processes (e.g. physical abuse and cardiovascular function), but also share a 'common' epigenetic signature enriched for biological processes related to neural development and organismal growth. A stringent set of sensitivity analyses were also run to identify high-confidence associations. Together, findings lend novel insights into epigenetic signatures of childhood abuse and neglect, point to novel potential biomarkers for future investigation and support a molecular link between maltreatment and poor health outcomes. Nevertheless, it will be important in future to replicate findings, as the use of cross-sectional data and high rates of polyvictimization in our study make it difficult to fully disentangle the shared vs unique epigenetic signatures of maltreatment types. Furthermore, studies will be needed to test the role of potential moderators in the identified associations, including age of onset and chronicity of maltreatment exposure.
Citation:
Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. 2016, 83:184-194 J Psychiatr Res
Publisher:
Elsevier
Journal:
Journal of psychiatric research
Issue Date:
Dec-2016
URI:
http://hdl.handle.net/11287/620265
DOI:
10.1016/j.jpsychires.2016.09.010
PubMed ID:
27643477
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0022395616303636
Note:
RD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.
Type:
Journal Article
Language:
en
ISSN:
1879-1379
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCecil, C.A.M.en
dc.contributor.authorSmith, Rebeccaen
dc.contributor.authorWalton, E.en
dc.contributor.authorMill, Jonathanen
dc.contributor.authorMcCrory, E.en
dc.contributor.authorViding, E.en
dc.date.accessioned2017-03-10T15:55:58Z-
dc.date.available2017-03-10T15:55:58Z-
dc.date.issued2016-12-
dc.identifier.citationEpigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. 2016, 83:184-194 J Psychiatr Resen
dc.identifier.issn1879-1379-
dc.identifier.pmid27643477-
dc.identifier.doi10.1016/j.jpsychires.2016.09.010-
dc.identifier.urihttp://hdl.handle.net/11287/620265-
dc.description.abstractChildhood maltreatment is a key risk factor for poor mental and physical health. Recently, variation in epigenetic processes, such as DNA methylation, has emerged as a potential pathway mediating this association; yet, the extent to which different forms of maltreatment may be characterized by unique vs shared epigenetic signatures is currently unknown. In this study, we quantified DNA methylation across the genome in buccal epithelial cell samples from a high-risk sample of inner-city youth (n = 124; age = 16-24; 53% female), 68% of whom reported experiencing at least one form of maltreatment while growing up. Our analyses aimed to identify methylomic variation associated with exposure to five major types of childhood maltreatment. We found that: (i) maltreatment types differ in the extent to which they associate with methylomic variation, with physical exposures showing the strongest associations; (ii) many of the identified loci are annotated to genes previously implicated in stress-related outcomes, including psychiatric and physical disorders (e.g. GABBR1, GRIN2D, CACNA2D4, PSEN2); and (iii) based on gene ontology analyses, maltreatment types not only show unique methylation patterns enriched for specific biological processes (e.g. physical abuse and cardiovascular function), but also share a 'common' epigenetic signature enriched for biological processes related to neural development and organismal growth. A stringent set of sensitivity analyses were also run to identify high-confidence associations. Together, findings lend novel insights into epigenetic signatures of childhood abuse and neglect, point to novel potential biomarkers for future investigation and support a molecular link between maltreatment and poor health outcomes. Nevertheless, it will be important in future to replicate findings, as the use of cross-sectional data and high rates of polyvictimization in our study make it difficult to fully disentangle the shared vs unique epigenetic signatures of maltreatment types. Furthermore, studies will be needed to test the role of potential moderators in the identified associations, including age of onset and chronicity of maltreatment exposure.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0022395616303636en
dc.rightsArchived with thanks to Journal of psychiatric researchen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleEpigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability.en
dc.typeJournal Articleen
dc.identifier.journalJournal of psychiatric researchen
dc.description.noteRD&E staff can access the full-text of this article via OpenAthens. Click on the 'Additional Link' above to access the full-text and log in with NHS OpenAthens if prompted.en
dc.type.versionPublisheden

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