Genetic Variation at 16q24.2 is associated with small vessel stroke.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620267
Title:
Genetic Variation at 16q24.2 is associated with small vessel stroke.
Authors:
Traylor, M.; Malik, R.; Nalls, M. A.; Cotlarciuc, I.; Radmanesh, F.; Thorleifsson, G.; Hanscombe, K. B.; Langefeld, C.; Saleheen, D.; Rost, N. S.; Yet, I.; Spector, T. D.; Bell, J. T.; Hannon, E.; Mill, Jonathan; Chauhan, G.; Debette, S.; Bis, J.C.; Longstreth, W. T.; Ikram, M. A.; Launer, L. J.; Seshadri, S.; Jimenez-Conde, J.; Cole, J. W.; Schmidt, R.; Słowik, A.; Lemmens, R.; Lindgren, A.; Melander, O.; Grewal, R. P.; Sacco, R. L.; Rundek, T.; Rexrode, K.; Arnett, D. K.; Johnson, J. A.; Benavente, O. R.; Wasssertheil-Smoller, S.; Lee, J-M; Pulit, S. L.; Wong, Q.; Rich, S. S.; de Bakker, P. I. W.; McArdle, P. F.; Woo, D.; Anderson, C. D.; Xu, H.; Heitsch, L.; Fornage, M.; Jern, C.; Stefansson, K.; Thorsteinsdottir, U.; Gretarsdottir, S.; Lewis, C. M.; Sharma, P.; Sudlow, C. L. M.; Rothwell, P. M.; Boncoraglio, G. B.; Thijs, V.; Levi, C.; Meschia, J. F.; Rosand, J.; Kittner, S. J.; Mitchell, B. D.; Dichgans, M.; Worrall, B. B.; Markus, H. S.
Abstract:
Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises a quarter of all ischaemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown younger onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger onset SVS population, to identify novel associations with stroke.
Citation:
Genetic Variation at 16q24.2 is associated with small vessel stroke. 2017 Mar;81(3):383-394. Epub 2016 Dec 20. Ann. Neurol.
Publisher:
Wiley
Journal:
Annals of Neurology
Issue Date:
20-Dec-2016
URI:
http://hdl.handle.net/11287/620267
DOI:
10.1002/ana.24840
PubMed ID:
27997041
Type:
Journal Article
Language:
en
ISSN:
1531-8249
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorTraylor, M.en
dc.contributor.authorMalik, R.en
dc.contributor.authorNalls, M. A.en
dc.contributor.authorCotlarciuc, I.en
dc.contributor.authorRadmanesh, F.en
dc.contributor.authorThorleifsson, G.en
dc.contributor.authorHanscombe, K. B.en
dc.contributor.authorLangefeld, C.en
dc.contributor.authorSaleheen, D.en
dc.contributor.authorRost, N. S.en
dc.contributor.authorYet, I.en
dc.contributor.authorSpector, T. D.en
dc.contributor.authorBell, J. T.en
dc.contributor.authorHannon, E.en
dc.contributor.authorMill, Jonathanen
dc.contributor.authorChauhan, G.en
dc.contributor.authorDebette, S.en
dc.contributor.authorBis, J.C.en
dc.contributor.authorLongstreth, W. T.en
dc.contributor.authorIkram, M. A.en
dc.contributor.authorLauner, L. J.en
dc.contributor.authorSeshadri, S.en
dc.contributor.authorJimenez-Conde, J.en
dc.contributor.authorCole, J. W.en
dc.contributor.authorSchmidt, R.en
dc.contributor.authorSłowik, A.en
dc.contributor.authorLemmens, R.en
dc.contributor.authorLindgren, A.en
dc.contributor.authorMelander, O.en
dc.contributor.authorGrewal, R. P.en
dc.contributor.authorSacco, R. L.en
dc.contributor.authorRundek, T.en
dc.contributor.authorRexrode, K.en
dc.contributor.authorArnett, D. K.en
dc.contributor.authorJohnson, J. A.en
dc.contributor.authorBenavente, O. R.en
dc.contributor.authorWasssertheil-Smoller, S.en
dc.contributor.authorLee, J-Men
dc.contributor.authorPulit, S. L.en
dc.contributor.authorWong, Q.en
dc.contributor.authorRich, S. S.en
dc.contributor.authorde Bakker, P. I. W.en
dc.contributor.authorMcArdle, P. F.en
dc.contributor.authorWoo, D.en
dc.contributor.authorAnderson, C. D.en
dc.contributor.authorXu, H.en
dc.contributor.authorHeitsch, L.en
dc.contributor.authorFornage, M.en
dc.contributor.authorJern, C.en
dc.contributor.authorStefansson, K.en
dc.contributor.authorThorsteinsdottir, U.en
dc.contributor.authorGretarsdottir, S.en
dc.contributor.authorLewis, C. M.en
dc.contributor.authorSharma, P.en
dc.contributor.authorSudlow, C. L. M.en
dc.contributor.authorRothwell, P. M.en
dc.contributor.authorBoncoraglio, G. B.en
dc.contributor.authorThijs, V.en
dc.contributor.authorLevi, C.en
dc.contributor.authorMeschia, J. F.en
dc.contributor.authorRosand, J.en
dc.contributor.authorKittner, S. J.en
dc.contributor.authorMitchell, B. D.en
dc.contributor.authorDichgans, M.en
dc.contributor.authorWorrall, B. B.en
dc.contributor.authorMarkus, H. S.en
dc.date.accessioned2017-03-13T09:49:00Z-
dc.date.available2017-03-13T09:49:00Z-
dc.date.issued2016-12-20-
dc.identifier.citationGenetic Variation at 16q24.2 is associated with small vessel stroke. 2017 Mar;81(3):383-394. Epub 2016 Dec 20. Ann. Neurol.en
dc.identifier.issn1531-8249-
dc.identifier.pmid27997041-
dc.identifier.doi10.1002/ana.24840-
dc.identifier.urihttp://hdl.handle.net/11287/620267-
dc.description.abstractGenome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises a quarter of all ischaemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown younger onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger onset SVS population, to identify novel associations with stroke.en
dc.language.isoenen
dc.publisherWileyen
dc.rightsArchived with thanks to Annals of neurologyen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleGenetic Variation at 16q24.2 is associated with small vessel stroke.en
dc.typeJournal Articleen
dc.identifier.journalAnnals of Neurologyen
dc.type.versionIn press (epub ahead of print)en

Related articles on PubMed

All Items in RD&E Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.