Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620280
Title:
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.
Authors:
Richardson, S. J.; Rodriguez-Calvo, T.; Gerling, I. C.; Mathews, C. E.; Kaddis, J. S.; Russell, M. A.; Zeissler, M.; Leete, P.; Krogvold, L.; Dahl-Jørgensen, K.; von Herrath, M.; Pugliese, A.; Atkinson, M. A.; Morgan, Noel
Abstract:
Human pancreatic beta cells may be complicit in their own demise in type 1 diabetes, but how this occurs remains unclear. One potentially contributing factor is hyperexpression of HLA class I antigens. This was first described approximately 30 years ago, but has never been fully characterised and was recently challenged as artefactual. Therefore, we investigated HLA class I expression at the protein and RNA levels in pancreases from three cohorts of patients with type 1 diabetes. The principal aims were to consider whether HLA class I hyperexpression is artefactual and, if not, to determine the factors driving it.
Citation:
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. 2016, 59 (11):2448-58 Diabetologia
Publisher:
Springer
Journal:
Diabetologia
Issue Date:
Nov-2016
URI:
http://hdl.handle.net/11287/620280
DOI:
10.1007/s00125-016-4067-4
PubMed ID:
27506584
Additional Links:
https://dx.doi.org/10.1007/s00125-016-4067-4
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1432-0428
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRichardson, S. J.en
dc.contributor.authorRodriguez-Calvo, T.en
dc.contributor.authorGerling, I. C.en
dc.contributor.authorMathews, C. E.en
dc.contributor.authorKaddis, J. S.en
dc.contributor.authorRussell, M. A.en
dc.contributor.authorZeissler, M.en
dc.contributor.authorLeete, P.en
dc.contributor.authorKrogvold, L.en
dc.contributor.authorDahl-Jørgensen, K.en
dc.contributor.authorvon Herrath, M.en
dc.contributor.authorPugliese, A.en
dc.contributor.authorAtkinson, M. A.en
dc.contributor.authorMorgan, Noelen
dc.date.accessioned2017-03-14T12:52:12Z-
dc.date.available2017-03-14T12:52:12Z-
dc.date.issued2016-11-
dc.identifier.citationIslet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. 2016, 59 (11):2448-58 Diabetologiaen
dc.identifier.issn1432-0428-
dc.identifier.pmid27506584-
dc.identifier.doi10.1007/s00125-016-4067-4-
dc.identifier.urihttp://hdl.handle.net/11287/620280-
dc.description.abstractHuman pancreatic beta cells may be complicit in their own demise in type 1 diabetes, but how this occurs remains unclear. One potentially contributing factor is hyperexpression of HLA class I antigens. This was first described approximately 30 years ago, but has never been fully characterised and was recently challenged as artefactual. Therefore, we investigated HLA class I expression at the protein and RNA levels in pancreases from three cohorts of patients with type 1 diabetes. The principal aims were to consider whether HLA class I hyperexpression is artefactual and, if not, to determine the factors driving it.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttps://dx.doi.org/10.1007/s00125-016-4067-4en
dc.rightsArchived with thanks to Diabetologiaen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleIslet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes.en
dc.typeJournal Articleen
dc.identifier.journalDiabetologiaen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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