Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections

2.50
Hdl Handle:
http://hdl.handle.net/11287/620293
Title:
Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections
Authors:
Scott, R. A.; Stone, Nick; Kendall, C.; Geraki, K.; Rogers, K.
Abstract:
Calcifications are not only one of the most important early diagnostic markers of breast cancer, but are also increasingly believed to aggravate the proliferation of cancer cells and invasion of surrounding tissue. Moreover, this influence appears to vary with calcification composition. Despite this, remarkably little is known about the composition and crystal structure of the most common type of breast calcifications, and how this differs between benign and malignant lesions. We sought to determine how the phase composition and crystallographic parameters within calcifications varies with pathology, using synchrotron X-ray diffraction. This is the first time crystallite size and lattice parameters have been measured in breast calcifications, and we found that these both parallel closely the changes in these parameters with age observed in fetal bone. We also discovered that these calcifications contain a small proportion of magnesium whitlockite, and that this proportion increases from benign to in situ to invasive cancer. When combined with other recent evidence on the effect of magnesium on hydroxyapatite precipitation, this suggests a mechanism explaining observations that carbonate levels within breast calcifications are lower in malignant specimens.
Citation:
Relationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections 2016, 2 (1) npj Breast Cancer
Publisher:
Nature
Journal:
npj Breast Cancer
Issue Date:
14-Sep-2016
URI:
http://hdl.handle.net/11287/620293
DOI:
10.1038/npjbcancer.2016.29
Additional Links:
http://www.nature.com/articles/npjbcancer201629
Type:
Journal Article
Language:
en
ISSN:
2374-4677
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorScott, R. A.en
dc.contributor.authorStone, Nicken
dc.contributor.authorKendall, C.en
dc.contributor.authorGeraki, K.en
dc.contributor.authorRogers, K.en
dc.date.accessioned2017-03-17T11:13:37Z-
dc.date.available2017-03-17T11:13:37Z-
dc.date.issued2016-09-14-
dc.identifier.citationRelationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sections 2016, 2 (1) npj Breast Canceren
dc.identifier.issn2374-4677-
dc.identifier.doi10.1038/npjbcancer.2016.29-
dc.identifier.urihttp://hdl.handle.net/11287/620293-
dc.description.abstractCalcifications are not only one of the most important early diagnostic markers of breast cancer, but are also increasingly believed to aggravate the proliferation of cancer cells and invasion of surrounding tissue. Moreover, this influence appears to vary with calcification composition. Despite this, remarkably little is known about the composition and crystal structure of the most common type of breast calcifications, and how this differs between benign and malignant lesions. We sought to determine how the phase composition and crystallographic parameters within calcifications varies with pathology, using synchrotron X-ray diffraction. This is the first time crystallite size and lattice parameters have been measured in breast calcifications, and we found that these both parallel closely the changes in these parameters with age observed in fetal bone. We also discovered that these calcifications contain a small proportion of magnesium whitlockite, and that this proportion increases from benign to in situ to invasive cancer. When combined with other recent evidence on the effect of magnesium on hydroxyapatite precipitation, this suggests a mechanism explaining observations that carbonate levels within breast calcifications are lower in malignant specimens.en
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttp://www.nature.com/articles/npjbcancer201629en
dc.rightsArchived with thanks to npj Breast Canceren
dc.subjectWessex Classification Subject Headings::Clinical pathologyen
dc.titleRelationships between pathology and crystal structure in breast calcifications: an in situ X-ray diffraction study in histological sectionsen
dc.typeJournal Articleen
dc.identifier.journalnpj Breast Canceren
dc.type.versionPublisheden
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