Towards new material biomarkers for fracture risk.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620294
Title:
Towards new material biomarkers for fracture risk.
Authors:
Greenwood, C; Clement, J; Dicken, A; Evans, J P O; Lyburn, I; Martin, R M; Rogers, K; Stone, Nick; Zioupos, P
Abstract:
Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) using dual energy X-ray absorption (DEXA). However, the risk of osteoporotic fracture is determined collectively by bone mass, architecture and physicochemistry of the mineral composite building blocks. Thus DEXA scans alone inevitably fail to fully discriminate individuals who will suffer a fragility fracture. This study examines trabecular bone at both ultrastructure and microarchitectural levels to provide a detailed material view of bone, and therefore provides a more comprehensive explanation of osteoporotic fracture risk. Physicochemical characterisation obtained through X-ray diffraction and infrared analysis indicated significant differences in apatite crystal chemistry and nanostructure between fracture and non-fracture groups. Further, this study, through considering the potential correlations between the chemical biomarkers and microarchitectural properties of trabecular bone, has investigated the relationship between bone mechanical properties (e.g. fragility) and physicochemical material features.
Citation:
Towards new material biomarkers for fracture risk. 2016, 93:55-63 Bone
Publisher:
Elsevier
Journal:
Bone
Issue Date:
Dec-2016
URI:
http://hdl.handle.net/11287/620294
DOI:
10.1016/j.bone.2016.09.006
PubMed ID:
27622884
Additional Links:
https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(16)30252-6
Type:
Journal Article
Language:
en
ISSN:
1873-2763
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGreenwood, Cen
dc.contributor.authorClement, Jen
dc.contributor.authorDicken, Aen
dc.contributor.authorEvans, J P Oen
dc.contributor.authorLyburn, Ien
dc.contributor.authorMartin, R Men
dc.contributor.authorRogers, Ken
dc.contributor.authorStone, Nicken
dc.contributor.authorZioupos, Pen
dc.date.accessioned2017-03-17T11:20:34Z-
dc.date.available2017-03-17T11:20:34Z-
dc.date.issued2016-12-
dc.identifier.citationTowards new material biomarkers for fracture risk. 2016, 93:55-63 Boneen
dc.identifier.issn1873-2763-
dc.identifier.pmid27622884-
dc.identifier.doi10.1016/j.bone.2016.09.006-
dc.identifier.urihttp://hdl.handle.net/11287/620294-
dc.description.abstractOsteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) using dual energy X-ray absorption (DEXA). However, the risk of osteoporotic fracture is determined collectively by bone mass, architecture and physicochemistry of the mineral composite building blocks. Thus DEXA scans alone inevitably fail to fully discriminate individuals who will suffer a fragility fracture. This study examines trabecular bone at both ultrastructure and microarchitectural levels to provide a detailed material view of bone, and therefore provides a more comprehensive explanation of osteoporotic fracture risk. Physicochemical characterisation obtained through X-ray diffraction and infrared analysis indicated significant differences in apatite crystal chemistry and nanostructure between fracture and non-fracture groups. Further, this study, through considering the potential correlations between the chemical biomarkers and microarchitectural properties of trabecular bone, has investigated the relationship between bone mechanical properties (e.g. fragility) and physicochemical material features.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S8756-3282(16)30252-6en
dc.rightsArchived with thanks to Boneen
dc.subjectWessex Classification Subject Headings::Orthopaedicsen
dc.titleTowards new material biomarkers for fracture risk.en
dc.typeJournal Articleen
dc.identifier.journalBoneen
dc.type.versionPublisheden
All Items in RD&E Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.