Characterisation of signal enhancements achieved when utilizing a photon diode in deep Raman spectroscopy of tissue.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620302
Title:
Characterisation of signal enhancements achieved when utilizing a photon diode in deep Raman spectroscopy of tissue.
Authors:
Vardaki, M. Z.; Matousek, P.; Stone, Nick
Abstract:
We characterise the performance of a beam enhancing element ('photon diode') for use in deep Raman spectroscopy (DRS) of biological tissues. The optical component enhances the number of laser photons coupled into a tissue sample by returning escaping photons back into it at the illumination zone. The method is compatible with transmission Raman spectroscopy, a deep Raman spectroscopy concept, and its implementation leads to considerable enhancement of detected Raman photon rates. In the past, the enhancement concept was demonstrated with a variety of samples (pharmaceutical tablets, tissue, etc) but it was not systematically characterized with biological tissues. In this study, we investigate the enhancing properties of the photon diode in the transmission Raman geometry as a function of: a) the depth and b) the optical properties of tissue samples. Liquid tissue phantoms were employed to facilitate systematic variation of optical properties. These were chosen to mimic optical properties of human tissues, including breast and prostate. The obtained results evidence that a photon diode can enhance Raman signals of tissues by a maximum of × 2.4, although it can also decrease the signals created towards the back of samples that exhibit high scattering or absorption properties.
Citation:
Characterisation of signal enhancements achieved when utilizing a photon diode in deep Raman spectroscopy of tissue. 2016, 7 (6):2130-41 Biomed Opt Express
Publisher:
Optical Society
Journal:
Biomedical optics express
Issue Date:
1-Jun-2016
URI:
http://hdl.handle.net/11287/620302
DOI:
10.1364/BOE.7.002130
PubMed ID:
27375932
Additional Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27375932/
Note:
This article is freely available. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
Appears in Collections:
Honorary contracts publications; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorVardaki, M. Z.en
dc.contributor.authorMatousek, P.en
dc.contributor.authorStone, Nicken
dc.date.accessioned2017-03-17T11:58:36Z-
dc.date.available2017-03-17T11:58:36Z-
dc.date.issued2016-06-01-
dc.identifier.citationCharacterisation of signal enhancements achieved when utilizing a photon diode in deep Raman spectroscopy of tissue. 2016, 7 (6):2130-41 Biomed Opt Expressen
dc.identifier.pmid27375932-
dc.identifier.doi10.1364/BOE.7.002130-
dc.identifier.urihttp://hdl.handle.net/11287/620302-
dc.description.abstractWe characterise the performance of a beam enhancing element ('photon diode') for use in deep Raman spectroscopy (DRS) of biological tissues. The optical component enhances the number of laser photons coupled into a tissue sample by returning escaping photons back into it at the illumination zone. The method is compatible with transmission Raman spectroscopy, a deep Raman spectroscopy concept, and its implementation leads to considerable enhancement of detected Raman photon rates. In the past, the enhancement concept was demonstrated with a variety of samples (pharmaceutical tablets, tissue, etc) but it was not systematically characterized with biological tissues. In this study, we investigate the enhancing properties of the photon diode in the transmission Raman geometry as a function of: a) the depth and b) the optical properties of tissue samples. Liquid tissue phantoms were employed to facilitate systematic variation of optical properties. These were chosen to mimic optical properties of human tissues, including breast and prostate. The obtained results evidence that a photon diode can enhance Raman signals of tissues by a maximum of × 2.4, although it can also decrease the signals created towards the back of samples that exhibit high scattering or absorption properties.en
dc.language.isoenen
dc.publisherOptical Societyen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27375932/en
dc.rightsArchived with thanks to Biomedical optics expressen
dc.subjectWessex Classification Subject Headings::Clinical pathologyen
dc.titleCharacterisation of signal enhancements achieved when utilizing a photon diode in deep Raman spectroscopy of tissue.en
dc.typeJournal Articleen
dc.identifier.journalBiomedical optics expressen
dc.description.noteThis article is freely available. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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