Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

2.50
Hdl Handle:
http://hdl.handle.net/11287/620326
Title:
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Authors:
Phelan, C. M. [et al]; Brewer, Carole
Abstract:
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC
Citation:
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nature Genetics 2017 May;49(5):680-691
Publisher:
Nature
Journal:
Nature Genetics
Issue Date:
May-2017
URI:
http://hdl.handle.net/11287/620326
DOI:
10.1038/ng.3826
PubMed ID:
28346442
Additional Links:
http://dx.doi.org/10.1038/ng.3826
Type:
Journal Article
Language:
en
Appears in Collections:
Clinical Genetics (Peninsula Genetics); 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPhelan, C. M. [et al]en
dc.contributor.authorBrewer, Caroleen
dc.date.accessioned2017-05-17T13:49:12Z-
dc.date.available2017-05-17T13:49:12Z-
dc.date.issued2017-05-
dc.identifier.citationIdentification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nature Genetics 2017 May;49(5):680-691en
dc.identifier.pmid28346442-
dc.identifier.doi10.1038/ng.3826-
dc.identifier.urihttp://hdl.handle.net/11287/620326-
dc.description.abstractTo identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOCen
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttp://dx.doi.org/10.1038/ng.3826en
dc.rightsArchived with thanks to Nature Geneticsen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleIdentification of 12 new susceptibility loci for different histotypes of epithelial ovarian canceren
dc.typeJournal Articleen
dc.identifier.journalNature Geneticsen
dc.type.versionPublisheden

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