The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain - A detailed case report.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620339
Title:
The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain - A detailed case report.
Authors:
Zeman, Adam; Hoefeijzers, S.; Milton, F.; Dewar, M.; Carr, M.; Streatfield, C.
Abstract:
We describe a patient in whom long-term, therapeutic infusion of the selective gamma-amino-butyric acid type B (GABAB) receptor agonist, baclofen, into the cerebrospinal fluid (CSF) gave rise to three distinct varieties of memory impairment: i) repeated, short periods of severe global amnesia, ii) accelerated long-term forgetting (ALF), evident over intervals of days and iii) a loss of established autobiographical memories. This pattern of impairment has been reported in patients with temporal lobe epilepsy (TLE), in particular the subtype of Transient Epileptic Amnesia (TEA). The amnesic episodes and accelerated forgetting remitted on withdrawal of baclofen, while the autobiographical amnesia (AbA) persisted. This exceptional case highlights the occurrence of 'non-standard' forms of human amnesia, reflecting the biological complexity of memory processes. It suggests a role for GABAB signalling in the modulation of human memory over multiple time-scales and hints at its involvement in 'epileptic amnesia'.
Citation:
The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain - A detailed case report. 2016, 74:9-19 Cortex
Publisher:
Elsevier
Journal:
Cortex; a journal devoted to the study of the nervous system and behavior
Issue Date:
Jan-2016
URI:
http://hdl.handle.net/11287/620339
DOI:
10.1016/j.cortex.2015.10.005
PubMed ID:
26599496
Additional Links:
https://linkinghub.elsevier.com/retrieve/pii/S0010-9452(15)00356-1
Type:
Case Report
Language:
en
ISSN:
1973-8102
Appears in Collections:
Neurology; 2016 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorZeman, Adamen
dc.contributor.authorHoefeijzers, S.en
dc.contributor.authorMilton, F.en
dc.contributor.authorDewar, M.en
dc.contributor.authorCarr, M.en
dc.contributor.authorStreatfield, C.en
dc.date.accessioned2017-05-24T13:23:43Z-
dc.date.available2017-05-24T13:23:43Z-
dc.date.issued2016-01-
dc.identifier.citationThe GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain - A detailed case report. 2016, 74:9-19 Cortexen
dc.identifier.issn1973-8102-
dc.identifier.pmid26599496-
dc.identifier.doi10.1016/j.cortex.2015.10.005-
dc.identifier.urihttp://hdl.handle.net/11287/620339-
dc.description.abstractWe describe a patient in whom long-term, therapeutic infusion of the selective gamma-amino-butyric acid type B (GABAB) receptor agonist, baclofen, into the cerebrospinal fluid (CSF) gave rise to three distinct varieties of memory impairment: i) repeated, short periods of severe global amnesia, ii) accelerated long-term forgetting (ALF), evident over intervals of days and iii) a loss of established autobiographical memories. This pattern of impairment has been reported in patients with temporal lobe epilepsy (TLE), in particular the subtype of Transient Epileptic Amnesia (TEA). The amnesic episodes and accelerated forgetting remitted on withdrawal of baclofen, while the autobiographical amnesia (AbA) persisted. This exceptional case highlights the occurrence of 'non-standard' forms of human amnesia, reflecting the biological complexity of memory processes. It suggests a role for GABAB signalling in the modulation of human memory over multiple time-scales and hints at its involvement in 'epileptic amnesia'.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0010-9452(15)00356-1en
dc.rightsArchived with thanks to Cortex; a journal devoted to the study of the nervous system and behavioren
dc.subjectWessex Classification Subject Headings::Neurologyen
dc.titleThe GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain - A detailed case report.en
dc.typeCase Reporten
dc.identifier.journalCortex; a journal devoted to the study of the nervous system and behavioren
dc.type.versionPublisheden

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