Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620344
Title:
Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial.
Authors:
Mowat, C.; Arnott, I.; Cahill, A.; Smith, M.; Ahmad, Tariq; Subramanian, S.; Travis, S.; Morris, J.; Hamlin, J.; Dhar, A.; Nwokolo, C.; Edwards, C.; Creed, T.; Bloom, S.; Yousif, M.; Thomas, L.; Campbell, S.; Lewis, S. J.; Sebastian, S.; Sen, S.; Lal, S.; Hawkey, C.; Murray, C.; Cummings, F.; Goh, J.; Lindsay, J. O.; Arebi, N.; Potts, L.; McKinley, A. J.; Thomson, J. M.; Todd, J. A.; Collie, M.; Dunlop, M. G.; Mowat, A.; Gaya, D. R.; Winter, J.; Naismith, G. D.; Ennis, H.; Keerie, C.; Lewis, S. C.; Prescott, R. J.; Kennedy, N. A.; Satsangi, J.
Abstract:
Up to 60% of patients with Crohn's disease need intestinal resection within the first 10 years of diagnosis, and postoperative recurrence is common. We investigated whether mercaptopurine can prevent or delay postoperative clinical recurrence of Crohn's disease.
Citation:
Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial. 2016, 1 (4):273-282 Lancet Gastroenterol Hepatol
Publisher:
Elsevier
Journal:
Lancet Gastroenterology & Hepatology
Issue Date:
Dec-2016
URI:
http://hdl.handle.net/11287/620344
DOI:
10.1016/S2468-1253(16)30078-4
PubMed ID:
28404197
Additional Links:
https://linkinghub.elsevier.com/retrieve/pii/S2468-1253(16)30078-4
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article; Randomized Controlled Trial
Language:
en
Description:
EDGE Project ID: 2508
ISSN:
2468-1253
Appears in Collections:
Gastroenterology; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMowat, C.en
dc.contributor.authorArnott, I.en
dc.contributor.authorCahill, A.en
dc.contributor.authorSmith, M.en
dc.contributor.authorAhmad, Tariqen
dc.contributor.authorSubramanian, S.en
dc.contributor.authorTravis, S.en
dc.contributor.authorMorris, J.en
dc.contributor.authorHamlin, J.en
dc.contributor.authorDhar, A.en
dc.contributor.authorNwokolo, C.en
dc.contributor.authorEdwards, C.en
dc.contributor.authorCreed, T.en
dc.contributor.authorBloom, S.en
dc.contributor.authorYousif, M.en
dc.contributor.authorThomas, L.en
dc.contributor.authorCampbell, S.en
dc.contributor.authorLewis, S. J.en
dc.contributor.authorSebastian, S.en
dc.contributor.authorSen, S.en
dc.contributor.authorLal, S.en
dc.contributor.authorHawkey, C.en
dc.contributor.authorMurray, C.en
dc.contributor.authorCummings, F.en
dc.contributor.authorGoh, J.en
dc.contributor.authorLindsay, J. O.en
dc.contributor.authorArebi, N.en
dc.contributor.authorPotts, L.en
dc.contributor.authorMcKinley, A. J.en
dc.contributor.authorThomson, J. M.en
dc.contributor.authorTodd, J. A.en
dc.contributor.authorCollie, M.en
dc.contributor.authorDunlop, M. G.en
dc.contributor.authorMowat, A.en
dc.contributor.authorGaya, D. R.en
dc.contributor.authorWinter, J.en
dc.contributor.authorNaismith, G. D.en
dc.contributor.authorEnnis, H.en
dc.contributor.authorKeerie, C.en
dc.contributor.authorLewis, S. C.en
dc.contributor.authorPrescott, R. J.en
dc.contributor.authorKennedy, N. A.en
dc.contributor.authorSatsangi, J.en
dc.date.accessioned2017-05-26T11:18:49Z-
dc.date.available2017-05-26T11:18:49Z-
dc.date.issued2016-12-
dc.identifier.citationMercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial. 2016, 1 (4):273-282 Lancet Gastroenterol Hepatolen
dc.identifier.issn2468-1253-
dc.identifier.pmid28404197-
dc.identifier.doi10.1016/S2468-1253(16)30078-4-
dc.identifier.urihttp://hdl.handle.net/11287/620344-
dc.descriptionEDGE Project ID: 2508en
dc.description.abstractUp to 60% of patients with Crohn's disease need intestinal resection within the first 10 years of diagnosis, and postoperative recurrence is common. We investigated whether mercaptopurine can prevent or delay postoperative clinical recurrence of Crohn's disease.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2468-1253(16)30078-4en
dc.rightsArchived with thanks to The lancet. Gastroenterology & hepatology.This article is available as Open Access under Creative Commons License CC-BY.en
dc.subjectWessex Classification Subject Headings::Gastroenterologyen
dc.titleMercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled trial.en
dc.typeJournal Articleen
dc.typeRandomized Controlled Trialen
dc.identifier.journalLancet Gastroenterology & Hepatologyen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.description.fundingMedical Research Council (07/MRE00/74)en
dc.type.versionPublisheden

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