Xenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620367
Title:
Xenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis.
Authors:
Lee, F-Y; Chen, K-H; Wallace, Christopher G ( 0000-0003-1897-9520 ) ; Sung, P-H; Sheu, J-J; Chung, S-Y; Chen, Y-L; Lu, H-I; Ko, S-F; Sun, C-K; Chiang, H-J; Chang, H-W; Lee, M S; Yip, H-K
Abstract:
This study tested the hypothesis that xenogeneic human umbilical cord-derived mesenchymal stem cell (HUCDMSC) therapy would improve survival rates in rats with acute respiratory distress-syndrome (ARDS, induction by 48 h inhalation of 100% oxygen) and sepsis-syndrome (SS, induction by cecal-ligation and puncture) (ARDS-SS). Adult-male Sprague-Dawley rats were categorized into group 1 (sham-controls), group 2 (ARDS-SS), group 3 [ARDS-SS+HUCDMSC (1.2 ×106 cells administered 1 h after SS-induction)], and group 4 [ARDS-SS+HUCDMSC (1.2 ×106 cells administered 24 h after SS-induction)]. The mortality rate was higher in groups 2 and 4 than in groups 1 and 3 (all p<0.0001). The blood pressure after 28 h was lower in groups 2, 3 and 4 (p<0.0001) than in group 1. Albumin levels and percentages of inflammatory cells in broncho-alveolar lavage fluid, and the percentages of inflammatory and immune cells in circulation, were lowest in group 1, highest in group 2, and higher in group 3 than group 4 (all p<0.0001). The percentages of inflammatory cells in ascites and kidney parenchyma showed identical patterns, as did kidney injury scores (all p<0.0001). EarlyHUCDMSC therapy reduced rodent mortality after induced ARDS-SS.
Citation:
Xenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis. 2017, 8 (28):45626-45642 Oncotarget
Publisher:
Oncotarget
Journal:
Oncotarget
Issue Date:
11-Jul-2017
URI:
http://hdl.handle.net/11287/620367
DOI:
10.18632/oncotarget.17320
PubMed ID:
28484089
Additional Links:
http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=17320
Note:
This article is freely available online. Click on the Additional Link above to access the full-text from the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1949-2553
Appears in Collections:
Plastic & Reconstructive Surgery; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLee, F-Yen
dc.contributor.authorChen, K-Hen
dc.contributor.authorWallace, Christopher Gen
dc.contributor.authorSung, P-Hen
dc.contributor.authorSheu, J-Jen
dc.contributor.authorChung, S-Yen
dc.contributor.authorChen, Y-Len
dc.contributor.authorLu, H-Ien
dc.contributor.authorKo, S-Fen
dc.contributor.authorSun, C-Ken
dc.contributor.authorChiang, H-Jen
dc.contributor.authorChang, H-Wen
dc.contributor.authorLee, M Sen
dc.contributor.authorYip, H-Ken
dc.date.accessioned2017-07-20T13:05:07Z-
dc.date.available2017-07-20T13:05:07Z-
dc.date.issued2017-07-11-
dc.identifier.citationXenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis. 2017, 8 (28):45626-45642 Oncotargeten
dc.identifier.issn1949-2553-
dc.identifier.pmid28484089-
dc.identifier.doi10.18632/oncotarget.17320-
dc.identifier.urihttp://hdl.handle.net/11287/620367-
dc.description.abstractThis study tested the hypothesis that xenogeneic human umbilical cord-derived mesenchymal stem cell (HUCDMSC) therapy would improve survival rates in rats with acute respiratory distress-syndrome (ARDS, induction by 48 h inhalation of 100% oxygen) and sepsis-syndrome (SS, induction by cecal-ligation and puncture) (ARDS-SS). Adult-male Sprague-Dawley rats were categorized into group 1 (sham-controls), group 2 (ARDS-SS), group 3 [ARDS-SS+HUCDMSC (1.2 ×106 cells administered 1 h after SS-induction)], and group 4 [ARDS-SS+HUCDMSC (1.2 ×106 cells administered 24 h after SS-induction)]. The mortality rate was higher in groups 2 and 4 than in groups 1 and 3 (all p<0.0001). The blood pressure after 28 h was lower in groups 2, 3 and 4 (p<0.0001) than in group 1. Albumin levels and percentages of inflammatory cells in broncho-alveolar lavage fluid, and the percentages of inflammatory and immune cells in circulation, were lowest in group 1, highest in group 2, and higher in group 3 than group 4 (all p<0.0001). The percentages of inflammatory cells in ascites and kidney parenchyma showed identical patterns, as did kidney injury scores (all p<0.0001). EarlyHUCDMSC therapy reduced rodent mortality after induced ARDS-SS.en
dc.language.isoenen
dc.publisherOncotargeten
dc.relation.urlhttp://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=17320en
dc.rightsArchived with thanks to Oncotarget.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.en
dc.subjectWessex Classification Subject Headings::Surgery::Plastic surgeryen
dc.titleXenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis.en
dc.typeJournal Articleen
dc.identifier.journalOncotargeten
dc.description.noteThis article is freely available online. Click on the Additional Link above to access the full-text from the publisher's site.en
dc.type.versionPublisheden

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