Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620398
Title:
Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion.
Authors:
Singh, R.; Keen, Charles Edward; Stone, Christopher; Sarsfield, Patrick
Abstract:
Langerhans cells are antigen presenting dendritic cells and tumours arising from these are rare. The tumours arising from these dendritic cells are divided into two categories according to a WHO classification: Langerhans cell histiocytosis and Langerhans cell sarcoma. It is the degree of atypia and clinical aggressiveness that distinguishes the two subtypes. Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells which can occur in skin, bone marrow, lymph nodes, spleen, liver, and lung. LCS can present with multiple cutaneous and systemic lesions. We present a case of Langerhans cell sarcoma with a unique morphological appearance and variable immunohistochemical profile within a single cutaneous lesion. LCS is a rare malignancy and its diagnosis is based on morphology, immunophenotypical examination, and ultrastructural analysis by electron microscopy. Our case highlights a unique morphological description of LCS wherein the pleomorphic neoplastic cells show epidermotropism and are surrounded by a variable amount of inflammatory infiltrate within a single cutaneous lesion. A single cutaneous lesion of Langerhans cell sarcoma with variable immunohistochemical profile has not been described so far.
Citation:
Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. 2017, 2017:9842605 Case Rep Pathol
Publisher:
Hindawi
Journal:
Case reports in pathology
Issue Date:
May-2017
URI:
http://hdl.handle.net/11287/620398
DOI:
10.1155/2017/9842605
PubMed ID:
28626593
Additional Links:
https://dx.doi.org/10.1155/2017/9842605
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article; Case Report
Language:
en
ISSN:
2090-6781
Appears in Collections:
Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology); 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSingh, R.en
dc.contributor.authorKeen, Charles Edwarden
dc.contributor.authorStone, Christopheren
dc.contributor.authorSarsfield, Patricken
dc.date.accessioned2017-09-11T15:02:18Z-
dc.date.available2017-09-11T15:02:18Z-
dc.date.issued2017-05-
dc.identifier.citationLangerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion. 2017, 2017:9842605 Case Rep Patholen
dc.identifier.issn2090-6781-
dc.identifier.pmid28626593-
dc.identifier.doi10.1155/2017/9842605-
dc.identifier.urihttp://hdl.handle.net/11287/620398-
dc.description.abstractLangerhans cells are antigen presenting dendritic cells and tumours arising from these are rare. The tumours arising from these dendritic cells are divided into two categories according to a WHO classification: Langerhans cell histiocytosis and Langerhans cell sarcoma. It is the degree of atypia and clinical aggressiveness that distinguishes the two subtypes. Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells which can occur in skin, bone marrow, lymph nodes, spleen, liver, and lung. LCS can present with multiple cutaneous and systemic lesions. We present a case of Langerhans cell sarcoma with a unique morphological appearance and variable immunohistochemical profile within a single cutaneous lesion. LCS is a rare malignancy and its diagnosis is based on morphology, immunophenotypical examination, and ultrastructural analysis by electron microscopy. Our case highlights a unique morphological description of LCS wherein the pleomorphic neoplastic cells show epidermotropism and are surrounded by a variable amount of inflammatory infiltrate within a single cutaneous lesion. A single cutaneous lesion of Langerhans cell sarcoma with variable immunohistochemical profile has not been described so far.en
dc.language.isoenen
dc.publisherHindawien
dc.relation.urlhttps://dx.doi.org/10.1155/2017/9842605en
dc.rightsArchived with thanks to Case reports in pathology. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.en
dc.titleLangerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion.en
dc.typeJournal Articleen
dc.typeCase Reporten
dc.identifier.journalCase reports in pathologyen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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