5-hydroxymethylcytosine is highly dynamic across human fetal brain development.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620420
Title:
5-hydroxymethylcytosine is highly dynamic across human fetal brain development.
Authors:
Spiers, H.; Hannon, E.; Schalkwyk, L. C.; Bray, N. J.; Mill, Jonathan
Abstract:
Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic processes operating during this period have not been extensively explored. Of particular interest is DNA hydroxymethylation (5hmC), a modification that is enriched in the human brain and hypothesized to play an important role in neuronal function, learning and memory. In this study, we quantify 5hmC across the genome of 71 human fetal brain samples spanning 23 to 184 days post-conception.
Citation:
5-hydroxymethylcytosine is highly dynamic across human fetal brain development. 2017, 18 (1):738 BMC Genomics
Publisher:
BioMed Central
Journal:
BMC genomics
Issue Date:
18-Sep-2017
URI:
http://hdl.handle.net/11287/620420
DOI:
10.1186/s12864-017-4091-x
PubMed ID:
28923016
Additional Links:
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4091-x
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1471-2164
Appears in Collections:
Honorary contracts publications; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSpiers, H.en
dc.contributor.authorHannon, E.en
dc.contributor.authorSchalkwyk, L. C.en
dc.contributor.authorBray, N. J.en
dc.contributor.authorMill, Jonathanen
dc.date.accessioned2017-10-04T13:20:08Z-
dc.date.available2017-10-04T13:20:08Z-
dc.date.issued2017-09-18-
dc.identifier.citation5-hydroxymethylcytosine is highly dynamic across human fetal brain development. 2017, 18 (1):738 BMC Genomicsen
dc.identifier.issn1471-2164-
dc.identifier.pmid28923016-
dc.identifier.doi10.1186/s12864-017-4091-x-
dc.identifier.urihttp://hdl.handle.net/11287/620420-
dc.description.abstractEpigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic processes operating during this period have not been extensively explored. Of particular interest is DNA hydroxymethylation (5hmC), a modification that is enriched in the human brain and hypothesized to play an important role in neuronal function, learning and memory. In this study, we quantify 5hmC across the genome of 71 human fetal brain samples spanning 23 to 184 days post-conception.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttps://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4091-xen
dc.rightsArchived with thanks to BMC genomicsen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.title5-hydroxymethylcytosine is highly dynamic across human fetal brain development.en
dc.typeJournal Articleen
dc.identifier.journalBMC genomicsen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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