Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620422
Title:
Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms.
Authors:
Janecka, M; Mill, Jonathan; Basson, M A; Goriely, A; Spiers, H; Reichenberg, A; Schalkwyk, L; Fernandes, C
Abstract:
Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders.
Citation:
Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms. 2017, 7 (1):e1019 Transl Psychiatry
Publisher:
Nature
Journal:
Translational psychiatry
Issue Date:
31-Jan-2017
URI:
http://hdl.handle.net/11287/620422
DOI:
10.1038/tp.2016.294
PubMed ID:
28140401
Additional Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28140401/
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
2158-3188
Appears in Collections:
Honorary contracts publications; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJanecka, Men
dc.contributor.authorMill, Jonathanen
dc.contributor.authorBasson, M Aen
dc.contributor.authorGoriely, Aen
dc.contributor.authorSpiers, Hen
dc.contributor.authorReichenberg, Aen
dc.contributor.authorSchalkwyk, Len
dc.contributor.authorFernandes, Cen
dc.date.accessioned2017-10-04T13:24:37Z-
dc.date.available2017-10-04T13:24:37Z-
dc.date.issued2017-01-31-
dc.identifier.citationAdvanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms. 2017, 7 (1):e1019 Transl Psychiatryen
dc.identifier.issn2158-3188-
dc.identifier.pmid28140401-
dc.identifier.doi10.1038/tp.2016.294-
dc.identifier.urihttp://hdl.handle.net/11287/620422-
dc.description.abstractMultiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders.en
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28140401/en
dc.rightsArchived with thanks to Translational psychiatryen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleAdvanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms.en
dc.typeJournal Articleen
dc.identifier.journalTranslational psychiatryen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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