Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620423
Title:
Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study.
Authors:
Walton, E; Pingault, J-B; Cecil, C A M; Gaunt, T R; Relton, C L; Mill, Jonathan; Barker, E D
Abstract:
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent developmental disorder, associated with a range of long-term impairments. Variation in DNA methylation, an epigenetic mechanism, is implicated in both neurobiological functioning and psychiatric health. However, the potential role of DNA methylation in ADHD symptoms is currently unclear. In this study, we examined data from the Avon Longitudinal Study of Parents and Children (ALSPAC)-specifically the subsample forming the Accessible Resource for Integrated Epigenomics Studies (ARIES)-that includes (1) peripheral measures of DNA methylation (Illumina 450k) at birth (n=817, 49% male) and age 7 (n=892, 50% male) and (2) trajectories of ADHD symptoms (7-15 years). We first employed a genome-wide analysis to test whether DNA methylation at birth associates with later ADHD trajectories; and then followed up at age 7 to investigate the stability of associations across early childhood. We found that DNA methylation at birth differentiated ADHD trajectories across multiple genomic locations, including probes annotated to SKI (involved in neural tube development), ZNF544 (previously implicated in ADHD), ST3GAL3 (linked to intellectual disability) and PEX2 (related to perixosomal processes). None of these probes maintained an association with ADHD trajectories at age 7. Findings lend novel insights into the epigenetic landscape of ADHD symptoms, highlighting the potential importance of DNA methylation variation in genes related to neurodevelopmental and peroxisomal processes that play a key role in the maturation and stability of cortical circuits.
Citation:
Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study. 2017, 22 (2):250-256 Mol. Psychiatry
Publisher:
Nature
Journal:
Molecular psychiatry
Issue Date:
Feb-2017
URI:
http://hdl.handle.net/11287/620423
DOI:
10.1038/mp.2016.85
PubMed ID:
27217153
Additional Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27217153/
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full text
Type:
Journal Article
Language:
en
ISSN:
1476-5578
Appears in Collections:
Honorary contracts publications; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorWalton, Een
dc.contributor.authorPingault, J-Ben
dc.contributor.authorCecil, C A Men
dc.contributor.authorGaunt, T Ren
dc.contributor.authorRelton, C Len
dc.contributor.authorMill, Jonathanen
dc.contributor.authorBarker, E Den
dc.date.accessioned2017-10-04T13:31:33Z-
dc.date.available2017-10-04T13:31:33Z-
dc.date.issued2017-02-
dc.identifier.citationEpigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study. 2017, 22 (2):250-256 Mol. Psychiatryen
dc.identifier.issn1476-5578-
dc.identifier.pmid27217153-
dc.identifier.doi10.1038/mp.2016.85-
dc.identifier.urihttp://hdl.handle.net/11287/620423-
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is a prevalent developmental disorder, associated with a range of long-term impairments. Variation in DNA methylation, an epigenetic mechanism, is implicated in both neurobiological functioning and psychiatric health. However, the potential role of DNA methylation in ADHD symptoms is currently unclear. In this study, we examined data from the Avon Longitudinal Study of Parents and Children (ALSPAC)-specifically the subsample forming the Accessible Resource for Integrated Epigenomics Studies (ARIES)-that includes (1) peripheral measures of DNA methylation (Illumina 450k) at birth (n=817, 49% male) and age 7 (n=892, 50% male) and (2) trajectories of ADHD symptoms (7-15 years). We first employed a genome-wide analysis to test whether DNA methylation at birth associates with later ADHD trajectories; and then followed up at age 7 to investigate the stability of associations across early childhood. We found that DNA methylation at birth differentiated ADHD trajectories across multiple genomic locations, including probes annotated to SKI (involved in neural tube development), ZNF544 (previously implicated in ADHD), ST3GAL3 (linked to intellectual disability) and PEX2 (related to perixosomal processes). None of these probes maintained an association with ADHD trajectories at age 7. Findings lend novel insights into the epigenetic landscape of ADHD symptoms, highlighting the potential importance of DNA methylation variation in genes related to neurodevelopmental and peroxisomal processes that play a key role in the maturation and stability of cortical circuits.en
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27217153/en
dc.rightsArchived with thanks to Molecular psychiatryen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Psychologyen
dc.subject.meshAdolescent-
dc.subject.meshAttention Deficit Disorder with Hyperactivity-
dc.subject.meshChild-
dc.subject.meshDNA Fingerprinting-
dc.subject.meshDNA Methylation-
dc.subject.meshEpigenesis, Genetic-
dc.subject.meshEpigenomics-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshLongitudinal Studies-
dc.subject.meshMale-
dc.subject.meshProspective Studies-
dc.titleEpigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study.en
dc.typeJournal Articleen
dc.identifier.journalMolecular psychiatryen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full texten
dc.type.versionPublisheden

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